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A multicenter feasibility study of chronic graft-versus-host disease according to the National Institute of Health criteria: efforts to establish a Brazil-Seattle consortium as a platform for future
TLDR
It was feasible to use the National Institute of Health consensus criteria for the diagnosis and scoring of chronic graft-versus-host disease in a Brazilian prospective multicenter study and a collaborative hematopoietic cell transplantation network was established in Brazil offering new opportunities for future clinical trials. Expand
Influence of fludarabine on the pharmacokinetics of oral busulfan during pretransplant conditioning for hematopoietic stem cell transplantation
TLDR
Although plasma busulfan concentrations were higher in patients receiving concomitant fludarabine, myelosuppression‐related toxicity was less frequent than in patients treated with busulf an and cyclophosphamide and no association was observed between busulfAn AUC0–6 and clinical evolution of the patients. Expand
Estimation of growth fraction in fine needle aspirates from non-Hodgkin's lymphoma using anti-proliferating cell nuclear antigen: correlation with the Kiel classification.
TLDR
The study showed that PCNA evaluation is suitable for smears obtained by FNA on NHL, correlates with increasing grades of lymphoma according to the Kiel classification and may offer a method of monitoring treatment of lymphomas. Expand
Methylation status of the SOCS 1 and JUNB genes in chronic myeloid leukemia patients
TLDR
Methylation of the promoter regions of the SOCS- 1 gene and the JUNB gene is not a frequent event in CML, but SOCS 1 gene methylation in exon2 is susceptible to alterations in status after hematopoietic stem cell transplantation with possible implications for the progression of this disease. Expand
Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay
TLDR
This work presents a nonsubjective, quantitative, sensitive, and inexpensive chemiluminescent technique that determines LAP based on the commercial reagent Immulite® (AMPPD), and validated this methodology with intact leukocytes obtained from 32 healthy subjects, nine CML patients, and nine LR patients. Expand
Influence of the Cell Source and Conditioning System on Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndrome.
TLDR
The results demonstrate the impact of conditioning and cell source on the HSCT outcome and reinforce the need for an appropriate assessment for better conduction results optimization. Expand
IMPACT OF TREATMENT PRIOR TO ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME: RESULTS OF THE LATIN AMERICAN BONE MARROW TRANSPLANT REGISTRY.
TLDR
The selection of pre-transplant bridge therapy should be analyzed and focus given primarily to those approaches that result in better survival of patients with MDS, including hypomethylating agents together with pre-HSCT chemotherapy. Expand