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Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat
This study tested the hypothesis that blockade of D-1 dopamine receptors in the nucleus accumbens shell, central nucleus of the amygdala or dorsal striatum by intracerebral microinjection of theExpand
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The Gerbil Elevated Plus-maze II: Anxiolytic-like Effects of Selective Neurokinin NK1 Receptor Antagonists
Neurokinin NK1 receptor antagonists may have therapeutic potential in the treatment of anxiety and depression. Species variants in the NK1 receptor result in reduced affinity of NK1 receptorExpand
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The Gerbil Elevated Plus-Maze I: Behavioral Characterization and Pharmacological Validation
Several neurokinin NK1 receptor antagonists currently being developed for anxiety and depression have reduced affinity for the rat and mouse NK1 receptor compared with human. Consequently, it hasExpand
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Acute extrapyramidal syndrome in Cebus monkeys: development mediated by dopamine D2 but not D1 receptors.
The present study assessed the role of dopamine D1 and D2 receptors in the production of an extrapyramidal syndrome (EPS) in Cebus apella monkeys. Previous studies have shown the development of EPSExpand
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The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
  • G. Varty, S. Lu, +11 authors G. Carey
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 1 August 2008
Orphanin FQ/nociceptin (OFQ/N) is the endogenously occurring peptide ligand for the nociceptin opioid receptor (NOP) that produces anxiolytic-like effects in mice and rats. The present study assessedExpand
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Behavioral and physiological effects of xanthines in nonhuman primates
Abstract Caffeine and related xanthines can have significant behavioral effects on measures of locomotor activity, schedule-controlled behavior, drug self-administration, and learning and memory.Expand
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Cholinergic improvement of a naturally-occurring memory deficit in the young rat
In a single-trial, passive-avoidance response (PAR) paradigm, young rats at post-natal day (PND) 16 were found to exhibit a performance deficit that diminished progressively with age. WhenExpand
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[3H]SCH 39166, A New D1‐Selective Radioligand: In Vitro and In Vivo Binding Analyses
SCH 39166 {(‐)‐trans‐6,7,7a,8,9,13b‐hexahydro‐3‐chloro‐2‐hydroxy‐N‐ methyl‐5H ‐ benzo ‐[d]naphtho[2,1b]azepine} has recently been described as a selective D1 antagonist and has entered clinicalExpand
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The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat.
We examined the discriminative stimulus effects of the high-efficacy dopamine D(1) receptor agonist (+/-)6-chloro-7, 8-dihydroxy-3-ally1-phenyl-2,3,4,5-tetrahydro-1H-3benzazepine++ + hydrobromideExpand
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Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity.
SCH39166 [(-)-trans-6,7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-N-methyl- 5H-benzo[d]naptho-(2,1-b)azepine] is a benzonaphthazepine that has been evaluated as a selective D1 dopamine receptorExpand
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