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The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
TLDR
OptiPrep density gradient centrifugation outperforms ultracentrifugation and ExoQuick and Total Exosome Isolation precipitation in terms of purity, and the purest exosome fractions reveal a unique mRNA profile enriched for translation, ribosome, mitochondrion and nuclear lumen function.
Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist, L-754,030, with ondansetron for the prevention of cisplatin-induced emesis.
TLDR
A single dose of L-758,298 substantially suppressed the delayed nausea and vomiting characteristic of high dose cisplatin and also appeared to reduce acute emesis post-cisplatin, supporting the proposition that the underlying mechanism(s) of acute and delayed emesis are different.
Third consensus on medical treatment of metastatic breast cancer.
TLDR
An international expert panel reviewed and discussed the evidence available from clinical trials regarding diagnostic, therapeutic and supportive measures with emphasis on their impact on the quality of life and overall survival of patients with metastatic breast cancer.
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
TLDR
Rab27B regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans.
Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study
TLDR
The data presented suggest that 99mTc-RP527 results in specific tumour localisation and exhibits good imaging characteristics with a good T/N ratio that may be further enhanced by single-photon emission tomography.
Combined karyotyping, CGH and M‐FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma
TLDR
A detailed description of chromosomal translocations occurring in MCC is provided that could be useful to direct future intensive investigation of these chromosomal regions.
Second consensus on medical treatment of metastatic breast cancer.
The present consensus manuscript defines evidence-based recommendations for state-of-the-art treatment of metastatic breast cancer depending on disease-associated and biologic variables.
Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT).
TLDR
In patients with metastatic uveal melanoma, the combination of selumetinib plus dacarbazine had a tolerable safety profile but did not significantly improve PFS compared with placebo plus dACarbazine.
Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma.
TLDR
Clinical and pathological responses are lower in ILC compared to IDC, and patients with large ILC should preferably be offered mastectomy with immediate breast reconstruction after PCT, but PCT still remains valuable to evaluate tumor response and biologic factors in vivo.
Mutation analysis of P73 and TP53 in Merkel cell carcinoma
TLDR
Results show that p73, analogous to neuroblastoma, is infrequently mutated in MCC, and this is also the first report in which the role of TP53 in Mcc has been investigated by sequencing the entire coding region of TP 53.
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