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Metabolic Inhibitors, Elicitors, and Precursors as Tools for Probing Yield Limitation in Taxane Production by Taxuschinensis Cell Cultures
Inhibition of biosynthetic enzymes and translation and translocation processes, elicitation, and precursor feeding were used to probe biosynthetic pathway compartmentation, substrate−productExpand
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Plants Used in the Management of Diabetic Complications
Diabetes is a disease, which has assumed vital public health importance because of the complications associated with it. Various mechanisms including polyol pathway along with a complex integratingExpand
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Application of microbial biotransformation for the new drug discovery using natural drugs as substrates.
This review describes microbial transformation studies of natural drugs, its importance in correlating them with the corresponding metabolism (biotransformation) in animal system and in theExpand
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Elicitation of Taxus sp. cell cultures for production of taxol
SummaryThe addition of cell extracts and cultures filtrate of Pencillium minioluteum, Botrytis cinerea, Verticillium dahliae, and Gilocladium deliqucescens on the tenth day after transferring TaxusExpand
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Camptothecine from callus cultures of Nothapodytes foetida
Callus cultures were established from excised embryos of Nothapodytes foetida on Murashige and Skoog medium supplemented with picloram (2 mg l−1) and 3% (w/v) sucrose. The embryos developed intoExpand
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Withaferin A from cell cultures of Withania somnifera
Suspension cultures of Withania somnifera cells were established and shown to produce withaferin A. The identification of withaferin A was done by TLC, UV absorption, HPLC and electron spray massExpand
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Production of camptothecines from callus cultures of Nothapodytes foetida (Wight) Sleumer
Murashige and Skoog (MS) medium supplemented with picloram (2 mg/l), Nbenzyladenine(BA) (1 mg/l) and gibberellic acid (GA3) (1 mg/l) was found to be suitable for the establishment of callus culturesExpand
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Pharmacokinetic and Pharmacodynamic Interaction of Curcumin with Glimepiride in Normal and Diabetic Rats
*Correspondence: Dr. Ciddi Veeresham, M.Pharm, Ph.D, PDF (USA), Professor of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal – 506009, Andhra Pradesh, India.Expand
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Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies.
BACKGROUND Various mechanisms with a complex integrating paradigm have been implicated in diabetic complications. The present study was aimed to evaluate the aldose reductase (AR) and advancedExpand
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Biotransformation of valdecoxib by microbial cultures.
Microbial biotransformations can be used to predict mammalian drug metabolism. The present investigation deals with microbial biotransformation of valdecoxib using microbial cultures. Thirty nineExpand
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