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Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissectionExpand
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Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin‐opening region to specific tissues
Locus control regions (LCRs) are thought to provide a dominant tissue‐specific open chromatin domain that allows for proper gene regulation by enhancers/silencers and their associated transcriptionExpand
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Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture
BackgroundBone marrow stromal cells (BMSCs) are a heterogeneous population that participates in wound healing, immune modulation and tissue regeneration. Next generation sequencing was used toExpand
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