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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
The viruses HIV-1, Epstein–Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV) are characterized by the establishment of lifelong infection in the human host, where their replication… Expand
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells
- L. Poulin, M. Salio, +14 authors C. Reis e Sousa
- Biology, Medicine
- The Journal of experimental medicine
- 7 June 2010
In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an important player in the regulation of T cell responses and a promising target in vaccination strategies. However,… Expand
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting… Expand
Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
Summary T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck. Here we showed that catalytically active Lck was… Expand
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation… Expand
Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.
The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell-mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E… Expand
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
We describe the cloning and characterization of Siglec-H, a novel murine CD33-related siglec-like molecule with 2 immunoglobulin domains. Unlike other CD33-related siglecs, Siglec-H lacks… Expand
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains
The human genome encodes five nonpolymorphic major histocompatibility complex class I–like glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T lymphocytes. Using… Expand
NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells 1
- I. Hermans, J. Silk, +7 authors V. Cerundolo
- Medicine, Biology
- The Journal of Immunology
- 15 November 2003
Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli or T cell help, plays a critical role in determining the quality and size of adaptive responses to Ag.… Expand
Biology of CD1- and MR1-restricted T cells.
Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in… Expand