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Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum.
It is suggested that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders. Expand
Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare.
The results suggest that marrubiin, like hydroalcoholic extract of M. vulgare, does not interact with opioid systems, and is more potent than some well-known analgesic drugs. Expand
Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae).
Marrubiin, a furane labdane diterpene, is the main analgesic compound present in Marrubium vulgare, a medicinal plant used in Brazil and other countries to treat several ailments, suggesting its possible use as a model to obtain new and potent analgesic agents. Expand
Antioedematogenic effect of marrubiin obtained from Marrubium vulgare.
The results demonstrate that the systemic administration of marrubiin exerts a non-specific inhibitory effect on pro-inflammatory agent-induced microvascular extravasation of Evans blue in mouse ear. Expand
Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory.
These results partly substantiate the traditional use of mate tea for improvement of cognition indicating that acute administration of hydroalcoholic extract of Ilex paraguariensis differentially modulates short- and long-term learning and memory in rats probably through its antagonist's action on adenosine receptors. Expand
Antinociceptive properties of the methanolic extract obtained from Ipomoea pes-caprae (L.) R. Br.
The results indicated that both methanolic extract and two fractions exhibited considerable antinociceptive activity against two classical models of pain in mice, supporting the popular use of I. pes-caprae to treat dolorous processes. Expand
Antinociceptive properties of conocarpan and orientin obtained from Piper solmsianum C. DC. var. solmsianum (Piperaceae)
The antinociceptive properties of some fractions and two pure compounds, conocarpan and orientin, obtained from P. solmsianum leaves were investigated in several models of pain in mice. The resultsExpand
Chemical composition and analgesic activity of Calophyllum brasiliense leaves.
The fractions and some phenolic compounds exhibited significant analgesic activity against the writhing test and in relation to the second phase (inflammatory pain) of the formalin test in mice, suggesting that this plant can be useful for the treatment of dolorous processes. Expand
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester.
GAEE produces dose-dependent and pronounced systemic, spinal and supraspinal antinociception in mice, probably via activation of K + channels and by a Gi/o pertussis toxin-sensitive mechanism. Expand
Analgesic triterpenes from Sebastiania schottiana roots.
The results suggest that the roots of S. schottiana contain analgesic compounds which justify, at least partially, the popular use of this plant for the treatment of urinary problems. Expand