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Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid
It is shown that zoledronic acid has marked antiangiogenic properties that could augment its efficacy in the treatment of malignant bone disease and extend its potential clinical use to other diseases with an angiogenic component. Expand
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets. Expand
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
Observations provide a conspicuous demonstration that HDAC inhibitors are potent anti-angiogenic factors altering VEGF signaling. Expand
The 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution.
A phylogenetic analysis indicated that all of the protein sequences derive from orthologous genes and that the 37LRP is indeed a ribosomal protein that acquired the novel function of laminin receptor during evolution. Expand
Evidence for a precursor of the high-affinity metastasis-associated murine laminin receptor.
The high-affinity cellular receptor for the basement membrane component laminin is differentially expressed during tumor invasion and metastasis. A cDNA clone encoding the murine laminin receptor wasExpand
Differential expression of galectin 3 and galectin 1 in colorectal cancer progression.
Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Expand
New insights into the metastasis‐associated 67 kD laminin receptor
The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form, and the function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin‐accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Expand
Formation of the 67‐kDa laminin receptor by acylation of the precursor
Data suggest that the 67LR is a heterodimer stabilized by strong intramolecular hydrophobic interactions, carried by fatty acids bound to the 37LRP and to a galectin3 cross‐reacting molecule, which is likely a palmitoylation process. Expand