• Publications
  • Influence
Circadian rhythms from multiple oscillators: lessons from diverse organisms
TLDR
Comparisons of circadian clocks in unicellular and multicellular organisms using molecular genetics and genomics have provided new insights into the mechanisms and complexity of clock systems.
The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.
TLDR
The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates.
Avian Melatonin Synthesis: Photic and Circadian Regulation of Serotonin N‐Acetyltransferase mRNA in the Chicken Pineal Gland and Retina
TLDR
It is determined that the chicken AA‐ NAT mRNA is detectable in follicular pineal cells and retinal photoreceptors and that it exhibits a circadian rhythm, with peak levels at night, and that changes in mRNA content are not involved in the rapid light‐induced decrease in AA‐NAT activity.
Immortal time: circadian clock properties of rat suprachiasmatic cell lines.
TLDR
Transplantation of SCN cell lines, but not mesencephalic or fibroblast lines, restored the circadian activity rhythm in arrhythmic, SCN-lesioned rats, indicating distinctive oscillator, pacemaker, and clock properties of the SCN are not only retained but also maintained in an appropriate circadian phase relationship by immortalized SCN progenitors.
Oscillating on Borrowed Time: Diffusible Signals from Immortalized Suprachiasmatic Nucleus Cells Regulate Circadian Rhythmicity in Cultured Fibroblasts
TLDR
It is suggested that expression and circadian regulation of the Per and Crygenes are not sufficient to confer pacemaker function, and SCN-specific outputs are necessary to drive circadian rhythms of metabolic activity, and these output signals are not a direct product of clock gene oscillations.
Comparative Anatomy of the Mammalian Hypothalamic Suprachiasmatic Nucleus
TLDR
These similarities suggest that the SCN developed char acteristic features early in mammalian phylogeny, and some details of SCN organization vary among the species studied.
Avian circadian organization: A chorus of clocks
  • V. Cassone
  • Biology
    Frontiers in Neuroendocrinology
  • 31 January 2014
Is the avian circadian system a neuroendocrine loop?
TLDR
A neuroendocrine loop is proposed in which the SCN inhibits pineal and ocular oscillators during the course of subjective day via a multisynaptic neuronal pathway which includes the superior cervical ganglia (SCG).
Circadian profiling of the transcriptome in immortalized rat SCN cells.
TLDR
Functional analyses and cartography indicate that a diverse set of cellular pathways are strategically regulated by the circadian clock in SCN2.2 cells and that the largest categories of rhythmic genes are those involved in cellular and systems-level communication or in metabolic processes like cellular respiration, fatty acid recycling, and steroid synthesis.
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