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Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons
It is the first connexin to be expressed predominantly in mammalian neurons and its identification paves the way for a molecular approach in the study of the role played by gap junctions in the physiology and the pathology of the mammalian brain.
Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs.
It is concluded that P-gp and MRPs are differently overexpressed in GPNT and RBE4 by various AEDs and both PXR and CAR are involved in the drug-resistant epilepsy induced by carbamazepine, phenobarbital and phenytoin.
An In Vitro Study of New Antiepileptic Drugs and Astrocytes
Investigating the biologic effects of these anticonvulsants (AEDs) at concentrations of 1, 10, 50, and 100 μg/ml found some biochemical modifications elicited in primary rat astrocyte cultures to be unusual.
Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins
The present findings substantiate a possible chemotherapeutic role of anthocyanins and suggest that CY and CY3G act on CaCo2 by different mechanisms, respectively, ROS-dependent and ROS-independent.
Indian medicinal plants as antiradicals and DNA cleavage protectors.
These antioxidant effects of active principle of CP, PK and WS may explain, at least in part, the reported anti-stress, immunomodulatory, cognition-facilitating, anti-inflammatory and antiaging effects produced by them in experimental animal and in clinical situations and may justify the further investigation of their other beneficial biological properties.
Protective Effect of Carnosine During Nitrosative Stress in Astroglial Cell Cultures
Carnosine protected against nitric oxide-induced impairment of mitochondrial function and was associated with decreased formation of oxidatively modified proteins and with decreased up-regulation oxidative stress-responsive genes, such as Hsp32, Hsp70 and mt-SOD.