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Biology of Zika Virus Infection in Human Skin Cells
TLDR
It is shown that human dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells are permissive to the most recent ZikV isolate, responsible for the epidemic in French Polynesia, and a major role is shown for the phosphatidylserine receptor AXL as a ZIKV entry receptor and for cellular autophagy in enhancing ZIKv replication in permissive cells.
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
TLDR
This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome, and because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillay-B Barré syndrome.
Potential Sexual Transmission of Zika Virus
TLDR
Observation supports the possibility that ZIKV could be transmitted sexually in women during pregnancy and during sexual intercourse.
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
TLDR
Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.
Detection of Zika virus in saliva.
TLDR
The use of saliva sample increased the rate of molecular detection of ZIKV at the acute phase of the disease but did not enlarge the window of detection ofZIKV RNA.
Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014.
TLDR
The results of specific nucleic acid testing of blood donors serve to alert blood safety authorities about the risk of post-transfusion Zika fever.
Structural basis of potent Zika-dengue virus antibody cross-neutralization.
TLDR
It is reported that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus, providing a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and d Dengue virus infections.
Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses.
TLDR
It is shown that Axl is expressed in human microglia and astrocytes in the developing brain and that itmediates ZIKV infection of glial cells and that inhibiting Axl function may represent a potential target for future antiviral therapies.
Emerging arboviruses in the Pacific
TLDR
A review of the epidemiological situation in the Pacifi c from the past several years shows that the present crisis could be the product of a gradual process, but substantial changes in epidemiology of mosquito-borne diseases in tropical oceanic regions are probably caused by many and difficult to address factors.
Zika Virus, French Polynesia, South Pacific, 2013
TLDR
The early investigations that led to identification of ZIKV as the causative agent of an outbreak that started in October 2013 in French Polynesia are reported.
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