• Publications
  • Influence
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases.
TLDR
Molecular dynamics pointed to the functional relevance of residues located in or close to the beta5-beta6 loop and allowed us to propose a mechanism for carbapenem hydrolysis by OXA-48. Expand
Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR
TLDR
The mechanistic basis of ALR–MIA40 interaction at atomic resolution is presented by biochemical and structural analyses of the mitochondrial ALR isoform and its covalent mixed disulfide intermediate with MIA40. Expand
A hint for the function of human Sco1 from different structures.
TLDR
The oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin function, and it is proposed that the various structures solved here represent the various states of the protein in its functional cycle and that the metal can be bound to the oxidized protein at a certain stage. Expand
Crystal structure of amine oxidase from bovine serum.
TLDR
The comparison of the BSAO structure with those of other resolved AO structures shows strong dissimilarities in the architecture and charge distribution of the cavities leading to the active-site, possibly explaining the differences in substrate specificity. Expand
The Evolutionarily Conserved Trimeric Structure of CutA1 Proteins Suggests a Role in Signal Transduction*
TLDR
The evolutionarily conserved trimeric assembly of CutA1 is reminiscent of the architecture of PII signal transduction proteins, which suggests an intriguing role ofcutA1 proteins in signalTransduction through allosteric communications between subunits. Expand
The crystal structure of yeast copper thionein: the solution of a long-lasting enigma.
TLDR
The present structure suggests that Cu-MT, in addition to its role as a safe depository for copper ions in the cell, may play an active role in the delivery of copper to metal-free chaperones. Expand
Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants
TLDR
The present results suggest that the investigation of the solution state coupled with that of the crystal state can provide major insights into SOD1 pathway toward oligomerization in relation to fALS. Expand
Crystal structure of the PsbQ protein of photosystem II from higher plants
TLDR
The smallest extrinsic polypeptide of the water‐oxidizing complex (PsbQ) was extracted and purified from spinach and its structure was determined by X‐ray diffraction at 1.95‐Å resolution using the multi‐wavelength anomalous diffraction method, with the zinc as the anomalous scatterer. Expand
Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.
TLDR
It appears that electrostatics is important in selecting which domain of the ATPase is able to form detectable amounts of the metal-mediated adduct with HAH1, and this observations provide a possible explanation for the low affinity of the two apoproteins. Expand
Conformational variability of matrix metalloproteinases: beyond a single 3D structure.
TLDR
It is proposed that many of the loops show a dynamical behavior in solution on a variety of time scales and backbone flexibility may play a role in the difficulties encountered in the design of selective inhibitors, whereas it may be a requisite for substrate binding and broad substrate specificity. Expand
...
1
2
3
4
5
...