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Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway.
- P. Adamson, S. Etienne, P. O. Couraud, V. Calder, J. Greenwood
- Biology, Medicine
- Journal of immunology
- 1 March 1999
Lymphocyte extravasation into the brain is mediated largely by the Ig superfamily molecule ICAM-1. Several lines of evidence indicate that at the tight vascular barriers of the central nervous system… Expand
Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures
- A. Leonardi, S. J. Curnow, H. Zhan, V. Calder
- Clinical and experimental allergy : journal of…
- 1 June 2006
Background Several cytokines are involved in the recruitment and activation of inflammatory cells in ocular allergic diseases. The purpose of the study was to assay multiple cytokines and chemokines… Expand
T-cell cytokines in chronic allergic eye disease.
- D. Metz, M. Hingorani, V. Calder, R. Buckley, S. Lightman
- The Journal of allergy and clinical immunology
- 1 December 1997
BACKGROUND The pathophysiology of chronic allergic eye disease cannot be explained by type I hypersensitivity alone, and T cell-mediated inflammation has been strongly implicated as a possible… Expand
Atopic keratoconjunctivitis and atopic dermatitis
- Stefano Guglielmetti, J. Dart, V. Calder
- Current opinion in allergy and clinical…
- 1 October 2010
Purpose of reviewThis review will focus on the diagnostic features of atopic keratoconjunctivitis (AKC), its relationship to atopic dermatitis, the immunopathogenesis, and therapy, and will include… Expand
Cytokines and chemokines in uveitis: is there a correlation with clinical phenotype?
Uveitis is a general term for intraocular inflammation and includes a large number of clinical phenotypes. As a group of disorders, it is responsible for 10% of all registered blind patients under… Expand
Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.
Lymphocyte adhesion to and migration across endothelial cell (EC) monolayers, derived from the rat blood-retinal barrier (BRB), were measured in vitro. The binding of concanavalin A (Con A)-activated… Expand
Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis.
OBJECTIVE Eotaxin-1 and eotaxin-2 are potent eosinophil chemotactic and activating peptides that may be implicated in the pathogenesis of the chronic allergic eye diseases vernal keratoconjunctivitis… Expand
IL6 and the human limbal stem cell niche: a mediator of epithelial-stromal interaction.
- M. Notara, A. Shortt, G. Galatowicz, V. Calder, J. Daniels
- Biology, Medicine
- Stem cell research
- 28 April 2009
The corneal epithelium is maintained by the limbal epithelial stem cells (LESCs). In this study, an in vitro model is proposed for the investigation of cell-cell interactions involving LESC… Expand
Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17
- S. Lightman, S. Taylor, +8 authors D. Haskard
- Annals of the rheumatic diseases
- 30 September 2014
Objective To determine whether the addition of 26 weeks of subcutaneous peginterferon-α-2b could reduce the requirement for systemic corticosteroids and conventional immunosuppressive medication in… Expand
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis.
- M. Hingorani, V. Calder, R. Buckley, S. Lightman
- Investigative ophthalmology & visual science
- 1 February 1999
PURPOSE To perform a detailed examination of the immunomodulatory effects of topical cyclosporin A (CsA) in conjunctival tissue from patients with atopic keratoconjunctivitis (AKC). METHODS… Expand