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Presence of the ica operon in clinical isolates of Staphylococcus epidermidis and its role in biofilm production.
TLDR
The results showed that icaRADBC was present in 45% of the isolates included in the study, and that such isolates were significantly more resistant to the main antibiotics tested than were ica-negative isolates, and there was evidence to suggest a correlation when at least two genes (icaAD) were co-transcribed. Expand
agr-Genotyping and transcriptional analysis of biofilm-producing Staphylococcus aureus.
TLDR
The data show that agr-II strains produce large amounts of biofilm, possess a defective agR-system show early transcription of icaA and are defective in haemolysin activity, icaR transcription, and in the expression of the sigma(B) activator rsbU. Expand
dltA overexpression: A strain-independent keystone of daptomycin resistance in methicillin-resistant Staphylococcus aureus.
TLDR
Findings highlight that dltA overexpression is the common pathway of resistance among genotypically different series of isolates and may represent the keystone of DAP resistance in MRSA, leading to electrostatic repulsion and, indirectly, to a reduction of autolysin activity. Expand
In vivo development of daptomycin resistance in vancomycin-susceptible methicillin-resistant Staphylococcus aureus severe infections previously treated with glycopeptides
TLDR
Daptomycin, as first-line therapy for the treatment of severe MRSA infections, should be used at optimal dosage combined with other agents such as beta-lactams, to prevent daptomecin resistance occurrence. Expand
Modulating Activity of Vancomycin and Daptomycin on the Expression of Autolysis Cell-Wall Turnover and Membrane Charge Genes in hVISA and VISA Strains
TLDR
Investigation of the relative quantitative expression of genes involved in autolysis, cell-wall turnover, membrane charges, regulatory mechanisms and regulatory mechanisms in hVISA and VISA cultured with or without vancomycin and daptomycin to better understand the molecular basis of vancomYcin-reduced susceptibility. Expand
Heteroresistance to glycopeptides in Italian meticillin-resistant Staphylococcus aureus (MRSA) isolates.
TLDR
It is demonstrated that hVISA isolates are common amongst MRSA isolates with MICs between 1mg/L and 2 mg/L in Italy, and MET, with its high sensitivity and specificity, should be used for early detection of hVisa, especially in patients with serious or prolonged infections sustained by MRSA. Expand
Pathotype and susceptibility profile of a community-acquired methicillin-resistant Staphylococcus aureus strain responsible for a case of severe pneumonia.
TLDR
A case of necrotizing pneumonia successfully treated with levofloxacin in Italy, sustained by a PVL-positive CA-MRSA, belonging to ST88 and carrying a staphylococcal chromosomal cassette mec type V is reported. Expand
Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management
TLDR
Results showed that children with AD as well as their cohabitants had a significantly greater incidence of S. aureus infection/colonization as compared to controls, suggesting both a direct transmission between the nasal reservoir and the lesions in the same atopic subject and a risk for reinfection within family cohabITants. Expand
Phenotypic and Genotypic Characterization of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Strains: Relative Roles of mprF and dlt Operons
TLDR
DAP-R in S. aureus appears to involve multi-factorial and strain-specific adaptive mechanisms, and changes in the compositional or biophysical order of the DAP CM target of such DAP- R strains may be essential to this phenotype. Expand
Infections with VIM-1 Metallo-β-Lactamase-Producing Enterobacter cloacae and Their Correlation with Clinical Outcome
TLDR
Enterobacter cloacae infections are difficult to diagnose due to an apparent susceptibility to various beta-lactams, including carbapenems, and are associated with a high relapse rate and a more prolonged duration of antibiotic therapy. Expand
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