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Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
Enteric neural crest cells (NCCs) migrate and colonize the entire gut and proliferate and differentiate into neurons and glia of the enteric nervous system in vertebrate embryos. We have investigatedExpand
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Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study
In this study, we performed a detailed topographical study on the development of ganglion plexuses and the smooth muscle layers of human embryonic and fetal gut. Neuron and glia differentiation wasExpand
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Tissue‐Specific and differential expression of alternatively spliced α1(II) collagen mRNAs in early human embryos
Expression of the α1(II) procollagen gene is not confined to chondrogenic tissues during vertebrate development. Transcripts of the human gene (COL2A1) are alternatively spliced to give mRNAs whichExpand
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Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells.
Prokineticins (Prok-1 and Prok-2) belong to a newly identified AVIT protein family. They are involved in variety of activities in various tissues, including smooth muscle contraction of theExpand
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Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice.
BACKGROUND & AIMS The enteric nervous system (ENS) controls intestinal peristalsis, and defective development of this system results in hypo/aganglionosis, as seen in Hirschsprung's disease. In theExpand
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Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3.
BACKGROUND Glioblastoma is a type of highly malignant primary brain tumour. By means of ion excretion and the associated obligatory water loss, glioma cells can change shapes and undergo extensiveExpand
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HOXB5 Cooperates with NKX2-1 in the Transcription of Human RET
The enteric nervous system (ENS) regulates peristaltic movement of the gut, and abnormal ENS causes Hirschsprung's disease (HSCR) in newborns. HSCR is a congenital complex genetic disorderExpand
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The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications for homotrimeric, heterotrimeric and heterotypic collagen molecules.
In cartilage collagen type XI exists as heterotrimeric molecules composed of alpha 1(XI), alpha 2(XI) and alpha 3(XI) subunits. Messenger RNAs for some of the alpha chains of collagen type XI haveExpand
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Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest.
Patterning of neural crest (NC) for the formation of specific structures along the anterio-posterior (A-P) body axis is governed by a combinatorial action of Hox genes, which are expressed in theExpand
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Analysis of SOX10 mutations identified in Waardenburg‐Hirschsprung patients: Differential effects on target gene regulation
SOX10 is a member of the SOX gene family related by homology to the high‐mobility group (HMG) box region of the testis‐determining gene SRY. Mutations of the transcription factor gene SOX10 lead toExpand
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