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A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology, and therapeutic potential
TLDR
Together this data strongly supports the view that the plants belonging to the genus Phyllanthus have potential beneficial therapeutic actions in the management of hepatitis B, nefrolitiase, and in painful disorders.
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Naturally occurring antinociceptive substances from plants
Despite the progress that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of…
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Quercetin: Further investigation of its antinociceptive properties and mechanisms of action
TLDR
The results indicate that quercetin produces dose-related anti-nociception in several models of chemical pain, through mechanisms that involve interaction with L-arginine-nitric oxide, serotonin, and GABAergic systems.
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Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.
TLDR
Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.
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Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
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Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles
TLDR
Plant extracts, fractions, and isolated compounds from some selected Brazilian medicinal plants against strains of promastigotes of Leishmania amazonensis and L. brasiliensis are concluded that the analyzed plants are promising as new and effective antiparasitic agents.
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A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
TLDR
Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes and all synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophyte.
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Evaluation of the antifungal activity and mode of action of Lafoensia pacari A. St.-Hil., Lythraceae, stem-bark extracts, fractions and ellagic acid
TLDR
Results indicate that ellagic acid might be the main active antifungal compound of Lafoensia pacari and suggest that the mode of antif fungus action of these extracts and ellagic Acid could be associated with the inhibition of fungal cell wall.
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Synthesis of chalcone analogues with increased antileishmanial activity.
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Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice.
TLDR
Its antinociceptive effect was insensitive to naloxone, suggesting the lack of involvement of endogenous opioid, was not modulated by adrenal glands and does not involve interaction with the L-arginine-nitric oxide pathway, activation of alpha-1 adrenoceptors or tau-aminobutyric acidB receptors, but requires, at least in part, the serotoninergic pathway.
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