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Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain
Pharmacological activities of optically pure enantiomers of the κ opioid agonist, U50,488, and its cis diastereomer: evidence for three κ receptor subtypes
Upregulation of the opioid receptor complex by the chronic administration of morphine: A biochemical marker related to the development of tolerance and dependence
Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences
Chronic haloperidol treatment up-regulates rat brain PCP receptors.
Probing the opioid receptor complex with (+)-trans-SUPERFIT. II. Evidence that μ ligands are noncompetitive inhibitors of the δ cx opioid peptide binding site
A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo.
The findings suggest that when administered in vivo, DALCE fails to distribute uniformly throughout the brain, and that it therefore binds covalently to opioid receptors mostly in the periventricular regions.
Evidence for four opioid kappa binding sites in guinea pig brain.
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
- R. Rothman, J. Long, V. Bykov, A. E. Jacobson, K. Rice, J. Holaday
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 November 1988
beta-Funaltrexamine (beta-FNA) is an alkylating derivative of naltrexone. Considerable data support its use as an irreversible mu receptor antagonist. However, pretreatment of rats with beta-FNA…