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Metabolites from the Sponge-Associated Bacterium Pseudomonas Species
Abstract: Quinolones and a phosphatidyl glyceride were isolated from the sponge-associated bacterial strain Pseudomonas sp. Structures were elucidated by spectroscopic analysis and chemicalExpand
Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome
The present study indicates that oxidative brain damage is a previously unrecognized hallmark feature of murine RTT, and suggests that Mecp2 is involved in the protection of the brain from oxidative stress. Expand
Isoprostanes and phytoprostanes: Bioactive lipids.
IsoP are now the most reliable indicators of oxidative stress in humans and how their biological roles may be clarified through new approaches based on analytical and synthetic organic chemistry are discussed. Expand
New pigments from the terrestrial cyanobacterium Scytonema sp. collected on the Mitaraka inselberg, French Guyana.
Inselbergs are hills rising abruptly from the surrounding plains where cyanobacteria are the only living organisms under conditions of intense solar radiation. A survival mechanism to preventExpand
New bromoditerpenes from the red alga Sphaerococcus coronopifolius.
Two new bromoditerpenes have been isolated from S. coronopifolius and were responsible for the antimalarial activity of the extract, against the chloroquine resistant Plasmodium falsciparum FCB1 strains with an IC(50) of 1 microM. Expand
Morphological, chemical and biochemical characterization of a new species of sponge without skeleton (Porifera, Demospongiae) from the Mediterranean Sea
Les sequences d'ARNr 28S confirment clairement les affinites de Thymosiopsis avec Thymosia, un genre de l'Atlantique Nord-Est qui differe par the possession d'un squelette tres original de fibres de spongine noduleuses. Expand
Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil
A significant reduction in the clinical severity together with a significant decrease in all the examined O.S. markers was observed in the ω-3 PUFAs supplemented patients, whereas no significant changes were evidenced in the untreated group. Expand
Lutoside: an acyl-1-(acyl-6′-mannobiosyl)-3-glycerol isolated from the sponge-associated bacterium Micrococcus luteus
Abstract Lutoside, an unusual acyl-1-(acyl-6′-mannobiosyl)-3-glycerol 1 was isolated from the sponge-associated bacterial strain Microccocus luteus. Sructure elucidation was performed byExpand
Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation
The findings suggest that the sensitivity of tumor cell lines to DHA involves oxidized metabolites, and suggest that NC seek to enhance the stability against degradation, enhance cellular availability, and control the release of bioactive fatty acids following their lipophilicities. Expand
Chemical and Bioactivity Evaluation of the Bark of Neonauclea purpurea
Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) andExpand