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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane.
Although rarely elicited during natural human infection, the most broadly neutralizing antibodies (BNAbs) against diverse human immunodeficiency virus (HIV)-1 strains target the membrane-proximalExpand
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Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network
MOTIVATION Prediction methods for identifying binding peptides could minimize the number of peptides required to be synthesized, and thereby facilitate the identification of potential T-cell epitopes. Expand
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes
Detection of somatic mutations in human leukocyte antigen (HLA) genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencingExpand
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MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides
A novel data representation method enables MULTIPRED to predict peptides that promiscuously bind multiple HLA alleles within one HLA supertype. Expand
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Methods for Prediction of Peptide Binding to MHC Molecules: A Comparative Study
BackgroundA variety of methods for prediction of peptide binding to major histocompatibility complex (MHC) have been proposed. These methods are based on binding motifs, binding matrices, hiddenExpand
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Computer model for recognition of functional transcription start sites in RNA polymerase II promoters of vertebrates.
This paper introduces a new computer system for recognition of functional transcription start sites (TSSs) in RNA polymerase II promoter regions of vertebrates. This system allows scanning completeExpand
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Dragon Promoter Finder: recognition of vertebrate RNA polymerase II promoters
Dragon Promoter Finder (DPF) locates RNA polymerase II promoters in DNA sequences of vertebrates by predicting Transcription Start Site (TSS) positions. Expand
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Prediction of promiscuous peptides that bind HLA class I molecules
Promiscuous T‐cell epitopes make ideal targets for vaccine development. We report here a computational system, multipred, for the prediction of peptide binding to the HLA‐A2 supertype. It combines aExpand
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MHCPEP, a database of MHC-binding peptides: update 1997
MHCPEP (http://wehih.edu.au/mhcpep/) is a curated database comprising over 13 000 peptide sequences known to bind MHC molecules. Expand
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Evaluation of MHC class I peptide binding prediction servers: Applications for vaccine research
BackgroundProtein antigens and their specific epitopes are formulation targets for epitope-based vaccines. A number of prediction servers are available for identification of peptides that bind majorExpand
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