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Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.
Compounds with amidic 'heads' with alkyloxy chains varying in length from 8 to 12 carbon atoms showed nanomolar affinity for both receptors, depending on the type of aromatic backbone, and two of the new compounds exhibit selectivity for CB(1) receptors. Expand
Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.
This study planned the synthesis of a series of compounds which retained both a rigid structure, like that of plant cannabinoids, and a flexible portion similar to that of anandamide, and showed that some of the newly developed compounds have high affinity and specificity for cannabinoid CB1 and CB2 receptors. Expand
High-performance liquid chromatographic determination of ambroxol in pharmaceuticals.
Conformational analysis of N‐arachidonylethanolamide (anandamide) using nuclear magnetic resonance and theoretical calculations
The conformational properties of cis‐5,8,11,14‐eicosatetraenoylethanolamide (anandamide) were analysed by the combined use of NMR experimental results plus molecular simulations. The structure ofExpand
New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.
The synthesis, docking studies, and structure-activity relationships of new resorcinol-anandamide "hybrids" differing in the side chain group are reported, with results similar to that of WIN 55-212. Expand
Rapid analysis of somatostatin in pharmaceutical preparations by HPLC with a micropellicular reversed-phase column.
The method is found to be highly selective and specific, as indicated by the baseline separation of a mixture containing somatostatin and two analogue peptides, which differ from the analyte for one and two amino acids, respectively. Expand
In vitro and in vivo pharmacology of synthetic olivetol‐ or resorcinol‐derived cannabinoid receptor ligands
The functional activity of CB‐25 and CB‐52, two ligands of CB1 and CB2 cannabinoid receptors, are assessed here. Expand
The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium.
This review covers the authors' work performed during the past decade in the development of 5-HT(3)R ligands belonging to the class of arylpiperazine derivatives related to quipazine and represents the extension of the review previously published in Current Topics in Medicinal Chemistry in 2002. Expand