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Atrial natriuretic peptide decreases contractility of cultured chick ventricular cells.
TLDR
Results indicate that r-ANP was able to decrease contractility of cultured cardiac myocytes and suggest a preferential antagonism of the inotropic effect of angiotensin II.
Central and peripheral cardiovascular effects of the enantiomers of the calcium antagonist PN 200-110.
TLDR
The results suggest that the dihydropyridine calcium channel antagonist, PN 200-110, may act centrally and stereoselectively at the level of the di hydrocarbon receptor sites involved in the control of blood pressure in spontaneously hypertensive rats.
CENTRAL CARDIOVASCULAR EFFECTS OF DIHYDROPYRIDINES IN SPONTANEOUSLY HYPERTENSIVE RATS
TLDR
The data suggest that central DHP sites may be involved in the cholinergic transmission and may participate in genetic hypertension via sympathetic tone in pentobarbital anesthetized spontaneously hypertensive rats (SMR).
Characterization of the angiotensin II AT1 receptor subtype involved in DNA synthesis in cultured vascular smooth muscle cells
TLDR
The results confirm that AII can stimulate DNA synthesis in VSMC through an AT1 receptor and are compatible with the AT1A receptor subtype recently described on cultured mesangial cells.
Relative negative inotropic potencies of nine calcium channel blockers in cultured heart cells.
TLDR
No significant difference in the direct negative inotropic potenties of nifedipine and nicardipine was shown in cultured chick embryo ventricular cells, where the effects of beating rate on the amplitude of contraction were taken into account.
Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger
TLDR
SL’59.1227 is the first example of a potent and NHE1‐selective non‐acylguanidine Na+/H+ exchanger inhibitor that possesses marked cardioprotective properties.
A G protein–biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers
TLDR
These findings demonstrate that sustained S1P1 activation can occur pharmacologically without compromising the immune response, providing a new approach to treat diseases associated with endothelial dysfunction and vascular hyperpermeability.
Interaction between isoproterenol and dihydropyridines in heart cells.
TLDR
Evidence is provided that activation of beta-adrenoceptors modulates the negative inotropic effect of nifedipine and nicardipine differently, and that isoproterenol shifts the entire dose-response curve for nifingipine to the right.
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
TLDR
This work supports the feasibility of identifying potent orally available CaMKII inhibitors suitable for clinical use to treat heart disease.
Activation of sarcolipin expression and altered calcium cycling in LMNA cardiomyopathy
TLDR
A novel role for sarcolipin on calcium homeostasis in heart and open perspectives for future therapeutic interventions to LMNA cardiomyopathy are showed.
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