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Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis
TLDR
Two genes in Saccharomyces cerevisiae, RCE1 and AFC1, were identified that appear to be responsible for the processing of prenylated proteins, which contain a covalently linked cholesterol intermediate near their carboxyl-termini. Expand
Multigenic control of Listeria monocytogenes susceptibility in mice
We have used a novel quantitative trait locus model to study the genetics of survival of F2 progeny of susceptible BALB/cByJ and resistant C57BL/6ByJ mice that have been infected with ListeriaExpand
The CaaX Proteases, Afc1p and Rce1p, Have Overlapping but Distinct Substrate Specificities
TLDR
In vitro assays indicated that farnesylation was compromised or undetectable for 11 a-factor variants that produced no detectable halo in the wild-type AFC1 RCE1 strain. Expand
Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis
TLDR
It is shown that the increased sensitivity of rtt109−/− cells to macrophages depends on the host’s ability to generate ROS, providing a mechanistic link between the drug sensitivity, gene expression, and pathogenesis phenotypes, and suggesting a unique target for therapeutic antifungal compounds. Expand
Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor
TLDR
It is concluded that mutations in Kif1C are responsible for the differences in the susceptibility of inbred mouse macrophages to LeTx and that proper K if1C function is required for LeTx resistance. Expand
Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor.
TLDR
This study provides additional genetic data supporting a direct role for Afc1p in cleavage of the carboxyl-terminal tripeptide from the CAAX motif of the prenylated a-factor precursor. Expand
A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity
TLDR
A crucial role is indicated for Tyk2 in T helper 1-mediated protective and pathogenic immune responses in human and animal populations and naturally occurring mutations in theTyk2 gene may underlie altered susceptibilities to infectious or autoimmune diseases in humanand animal populations. Expand
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
TLDR
Evidence is presented that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages, suggesting that it has a fundamental role in the mammalian secretory apparatus. Expand
Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.
TLDR
A metastatic HCC model generated after the somatic introduction of the mouse polyoma virus middle T antigen to mice with liver-specific deletion of the Trp53 tumor suppressor locus is described and data illustrate a new model system amenable for the analysis of HCC metastasis. Expand
Resistance of Haemophilus influenzae to Reactive Nitrogen Donors and Gamma Interferon-Stimulated Macrophages Requires the Formate-Dependent Nitrite Reductase Regulator-Activated ytfE Gene
TLDR
A requirement for FNR in positive control of yTFE is identified and indicate a critical role for ytfE in resistance of H. influenzae to reactive nitrogen species and the antibacterial effects of macrophages. Expand
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