• Publications
  • Influence
Sonic hedgehog signaling is essential for hair development
BACKGROUND The skin is responsible for forming a variety of epidermal structures that differ amongst vertebrates. In each case the specific structure (for example scale, feather or hair) arises fromExpand
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Noggin is a mesenchymally derived stimulator of hair-follicle induction
The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogeneticExpand
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Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
Lysosomal cysteine proteinases of the papain family are involved in lysosomal bulk proteolysis, major histocompatibility complex class II mediated antigen presentation, prohormone processing, andExpand
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Noggin is required for induction of the hair follicle growth phase in postnatal skin
During postnatal development, the hair follicle (HF) shows cyclic activity with periods of relative resting, active growth (anagen), and regression. We demonstrate that similar to the HF induction inExpand
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Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
The Notch and Calcineurin/NFAT pathways have both been implicated in control of keratinocyte differentiation. Induction of the p21(WAF1/Cip1) gene by Notch 1 activation in differentiatingExpand
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Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles.
Increasing evidence suggests that morphogenesis of the distinct developmental structures derived from the same organ-committed epithelium is controlled by differential mechanisms. As was recentlyExpand
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Molecular biology of hair morphogenesis: development and cycling.
In mammals, hair follicles produce hairs that fulfill a number of functions including thermoregulation, collecting sensory information, protection against environmental trauma, social communication,Expand
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Bone morphogenetic proteins and their antagonists in skin and hair follicle biology.
  • V. Botchkarev
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 2003
Bone morphogenetic proteins (BMP) are members of the transforming growth factor-beta superfamily regulating a large variety of biologic responses in many different cells and tissues during embryonicExpand
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Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma
The role of nerve growth factor (NGF), a potent mediator acting in the development and differentitation of both neuronal and immune cells, was examined in a mouse model of allergic asthma.Expand
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Control of murine hair follicle regression (catagen) by TGF‐β1 in vivo
The regression phase of the hair cycle (catagen) is an apoptosis‐driven process accompanied by terminal differentiation, proteolysis, and matrix remodeling. As an inhibitor of keratinocyteExpand
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