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Nicotine regulates basic fibroblastic growth factor and transforming growth factor beta1 production in endothelial cells.
Nicotine, a constituent of cigarette smoking, may induce atherosclerosis through the production of growth factors. The pattern of bFGF and TGF beta1 production and release by bovine aorticExpand
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Nicotine induces platelet-derived growth factor release and cytoskeletal alteration in aortic smooth muscle cells.
BACKGROUND Cigarette smoking is implicated in atherosclerotic plaque formation, but the role of nicotine in this process is not completely understood. The release of platelet-derived growth factorExpand
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Thrombin induces production of growth factors from aortic smooth muscle cells.
BACKGROUND Myointimal hyperplasia is a common complication of arterial recontructive surgery. The serine protease thrombin has a major role in vessel wall healing and eventual myointimal hyperplasiaExpand
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Bimodal concentration-dependent effect of thrombin on endothelial cell proliferation and growth factor release in culture.
BACKGROUND The role of thrombin in the stimulation of endothelial cell (EC) proliferation is controversial. The aim of this study was to investigate if thrombin regulates cell proliferation andExpand
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The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes‐derived soluble factor(s)
Ex vivo rat brain microvessels express receptors for native as well as for oxidized low‐density lipoproteins. In brain microvessels‐derived endothelial cells, the expression levels of both receptorsExpand
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Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin‐induced mitogenesis in smooth muscle cells
Thrombin is known to stimulate smooth muscle cell (SMC) growth in culture but the mechanisms underlying growth stimulation remain unclear. Previous works have observed a significant increase inExpand
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MMP and TIMP alterations in asymptomatic and symptomatic severe recurrent carotid artery stenosis.
OBJECTIVES This study aimed to determine whether the plasma levels of matrix metalloproteinases (MMPs)-2 and -9 and their specific inhibitors (tissue inhibitors of metalloproteinases (TIMPs-1 andExpand
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Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells.
BACKGROUND Vascular endothelial growth factor (VEGF), a highly specific chemotactic and mitogenic factor for vascular endothelial cells (EC), appears to be involved in the development ofExpand
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Nicotine-induced smooth muscle cell proliferation is mediated through bFGF and TGF-beta 1.
BACKGROUND Cigarette smoking influences and enhances the development of atherosclerosis. We investigated if nicotine, an important constituent of cigarette smoking, has a stimulatory effect on bovineExpand
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Shear stress induces transforming growth factor-beta 1 release by arterial endothelial cells.
BACKGROUND Myointimal hyperplasia is a common complication after vascular reconstruction. Increasing shear stress has been shown to reduce formation of myointimal hyperplasia. The aims of our studyExpand
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