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Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.
The present study provides evidence for liver and renal toxicity of (PhTe)(2) as well as potential toxic effects of diphenyl diselenide, Diphenyl ditelluride and Ebselen in rats and mice. Expand
Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats.
Cerebral Na(+), K(+)-ATPase is a potential molecular target for the toxic effect of organochalcogens and the inhibition may occur through a change in the crucial thiol groups of this enzyme. Expand
Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats.
Treatment with diphenyl diselenide, at all doses, effectively protects the increase of lipid peroxidation when compared to 2-NP group. Expand
Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro.
It is suggested that organochalcogens inactivate in vitro human erythrocyte delta-ALA-D by an interaction with the sulfhydryl group essential of the enzyme activity. Expand
Delta-aminolevulinate dehydratase (δ-ALA-D) activity in diabetes and hypothyroidism
AbstractObjectives: This study analyzed the influence of type 2 diabetes mellitus and primary hypothyroidism on the activity of the delta-aminolevulinate dehydratase (δ-ALA-D) in human blood.DesignExpand
Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents.
An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence ofExpand
Heavy Metals Modulate Glutamatergic System in Human Platelets
The present limited results could suggest that glutamatergic system may be used as a potential biomarker for neurotoxic action of heavy metals in humans. Expand
The role of thiol-reducing agents on modulation of glutamate binding induced by heavy metals in platelets.
Dithiol-reducing agents are capable of altering Hg2+, Pb2+ and Cd2+ effects on platelet glutamatergic system, indicating that in vitro data on chelating-metal interactions provide only an estimated guide to the treatment of heavy metal poisoning. Expand
Bis selenide alkene derivatives: A class of potential antioxidant and antinociceptive agents
The antinociception effect of 1c and 1d was not abolished by naloxone (an antagonist of opioid receptor, 1mg/kg, subcutaneously), suggesting that the ant inociceptive effect is not influenced by the opioidergic mechanism. Expand
Evaluation of antioxidant activity and potential toxicity of 1-buthyltelurenyl-2-methylthioheptene.
In vitro, compound 1 at 1 microM was effective in reducing lipid peroxidation induced by Fe/EDTA and is a promising compound for more detailed pharmacological studies involving organotellurium compounds. Expand