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SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology
TLDR
It is described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Criteria for good assessment: Consensus statement and recommendations from the Ottawa 2010 Conference
TLDR
Criteria for good assessment are outlined that include: (1) validity or coherence, (2) reproducibility or consistency, (3) equivalence, (4) feasibility, (5) educational effect, (6) catalytic effect, and (7) acceptability.
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial
TLDR
Once death was an uncommon event, it is not possible to ensure that colchicine reduced mortality of COVID-19, and the drug was safe and well tolerated.
2018 Consensus framework for good assessment
TLDR
A new set of criteria that apply to systems of assessment is presented and, recognizing the challenges of implementation, offers several issues for further consideration.
Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial
TLDR
The use of colchicine reduced the length of supplemental oxygen therapy and thelength of hospitalization and clinical improvement was in parallel with a reduction on serum levels of C-reactive protein.
SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology
TLDR
Results unravel a possible detrimental role of NETs in the pathophysiology of COVID-19 and suggest that the inhibition ofNETs represent a potential therapeutic target for CO VID-19.
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
TLDR
The immunological biosignature pattern of HAART 1 is similar to that of NI individuals, especially in patients presenting slow progression of the disease, while patients under HAART 2 remain in a moderate inflammatory state, which is similarto that of untreated HIV patients pattern.
McFarland nephelometer as a simple method to estimate the sensitivity of the polymerase chain reaction using Mycobacterium tuberculosis as a research tool.
TLDR
The use of McFarland nephelometer, a very simple approach to determine microorganism concentration in solution, for PCR standardization and DNA quantitation, using Mycobacterium tuberculosis as a model is described.
Self- and peer assessment may not be an accurate measure of PBL tutorial process
TLDR
Peer- and self-assessment marks might be reliable but not valid for PBL tutorial process, especially if these assessments are used for summative assessment, composing the final grade.
Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis.
TLDR
INH mutations varied geographically; molecular DST can be used to guide and accelerate decision making in the use of ETH or high doses of INH.
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