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Cognitive Strategies Dependent on the Hippocampus and Caudate Nucleus in Human Navigation: Variability and Change with Practice
- G. Iaria, M. Petrides, A. Dagher, B. Pike, V. Bohbot
- Psychology, BiologyThe Journal of Neuroscience
- 2 July 2003
The results provide the first evidence for spontaneous variability and shift in neural mechanisms during navigation in humans.
Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex
Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning
Gray Matter Differences Correlate with Spontaneous Strategies in a Human Virtual Navigation Task
- V. Bohbot, J. Lerch, Brook Thorndycraft, G. Iaria, A. Zijdenbos
- Biology, PsychologyThe Journal of Neuroscience
- 19 September 2007
Young healthy participants spontaneously use different strategies in a virtual radial maze, an adaptation of a task typically used with rodents, and data suggest that spatial strategies may provide protective effects against degeneration of the hippocampus that occurs with normal aging.
Hippocampal function and spatial memory: evidence from functional neuroimaging in healthy participants and performance of patients with medial temporal lobe resections.
Using a virtual environment, the authors identified 2 strategies dependent on 2 different memory systems: a spatial strategy involved the use of multiple landmarks available in the environment, and a response strategy involved right and left turns from a given start position.
Virtual navigation strategies from childhood to senescence: evidence for changes across the life span
The results suggest that while children predominantly use spatial strategies, the proportion of participants using spatial strategies decreases across the life span, in favor of response strategies, which has important implications regarding factors involved in healthy and successful aging.
Eye tracking, strategies, and sex differences in virtual navigation
Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation
- V. Bohbot, Milagros S. Copara, J. Gotman, A. Ekstrom
- Biology, PsychologyNature communications
- 14 February 2017
This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual.
Decreased functional magnetic resonance imaging activity in the hippocampus in favor of the caudate nucleus in older adults tested in a virtual navigation task
- K. Konishi, N. Etchamendy, Shumita Roy, A. Marighetto, Natasha Rajah, V. Bohbot
- Psychology, BiologyHippocampus
- 1 November 2013
The findings suggest that the aging process involves a shift from using the hippocampus toward the caudate nucleus during navigation but that activity in the hippocampus is sustained in a subset of healthy older adults engaged in spatial strategies.
Spontaneous navigational strategies and performance in the virtual town
The 4‐on‐8 virtual maze provides evidence for variability in spontaneous strategy use during navigation. Functional magnetic resonance imaging (MRI) confirmed that these spatial and response…