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The Maf transcription factors: regulators of differentiation.
Since the identification of the v-maf oncogene in an avian tumor virus, the Maf protein family has grown rapidly, forming a unique subclass of basic-leucine zipper transcription (bZIP) factors. MafExpand
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HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.
Heme oxygenase-1 (HO-1) is a key cytoprotective enzyme and an established marker of oxidative stress. Increased HO-1 expression has been found in the resident macrophages in the alveolar spaces ofExpand
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Curcumin alters EpRE and AP‐1 binding complexes and elevates glutamate‐cysteine ligase gene expression
Dietary use of curcumin, the active component of tumeric, one of the most widely used spices, is linked to several beneficial health effects, although the underlying molecular mechanisms remainExpand
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Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells
  • P. Gong, B. Hu, +5 authors J. Alam
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 20 July 2001
We have shown previously that activation of the heme oxygenase-1 (ho-1) gene by hypoxia in aortic smooth muscle cells is mediated by hypoxia-inducible factor-1 (HIF-1). In mutant (Ka13) ChineseExpand
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Characterization of the Hematopoietic Transcription Factor NF-E2 in Primary Murine Megakaryocytes*
Biochemical analysis of megakaryocytes, the precursors of blood platelets, is limited by their rarity in vivo, and studies on lineage-specific gene expression have been conducted exclusively in cellExpand
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NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors
NFE2L3 [Nuclear factor (erythroid-derived 2)-like 3] or NRF3, a member of the Cap‘n’Collar (CNC) family, is a basic-region leucine zipper (bZIP) transcription factor that was first identified over 10Expand
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Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?
  • V. Blank
  • Biology, Medicine
  • Journal of molecular biology
  • 29 February 2008
The small Maf basic leucine zipper (bZIP) proteins MafF, MafG and MafK, while modest in size, have emerged as crucial regulators of mammalian gene expression. Intriguingly, small Mafs do not containExpand
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Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus
ABSTRACT Cap'n'collar (CNC) family basic leucine zipper transcription factors play crucial roles in the regulation of mammalian gene expression and development. To determine the in vivo function ofExpand
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Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif.
  • W. Li, S. Yu, +4 authors A. Kong
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1 October 2008
Nrf2 is the key transcription factor regulating the antioxidant response. When exposed to oxidative stress, Nrf2 translocates to cell nucleus and forms heterodimer with small Maf proteins (sMaf).Expand
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Functional and placental expression analysis of the human NRF3 transcription factor.
Members of the Maf protooncogene and cap'n' collar families of basic-leucine zipper transcription factors play important roles in development, differentiation, oncogenesis, and stress signaling. InExpand
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