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Neural Tissue in Ascidian Embryos Is Induced by FGF9/16/20, Acting via a Combination of Maternal GATA and Ets Transcription Factors
A Quantitative Approach to the Study of Cell Shapes and Interactions during Early Chordate Embryogenesis
Early steps in the formation of neural tissue in ascidian embryos.
The organisation of the ascidian nervous system and its lineage is reviewed, and the current understanding of the processes of neural specification and patterning before and during gastrulation is focused on.
Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans.
A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian ectoderm
A precise combinatorial code of maternal factors responsible for zygotic onset of a chordate ectodermal genetic program is identified.
Analysis of Multiple Ethyl Methanesulfonate-Mutagenized Caenorhabditis elegans Strains by Whole-Genome Sequencing
The genome-wide mutational profile of 17 EMS-mutagenized genomes as assessed with a bioinformatic pipeline, called MAQGene, finds that while outcrossing mutagenized strains does reduce the total number of mutations, a striking mutational load is still observed even in outcrossed strains.
Making very similar embryos with divergent genomes: conservation of regulatory mechanisms of Otx between the ascidians Halocynthia roretzi and Ciona intestinalis
It is proposed that a combination of simplicity and degeneracy allows the conservation of the regulatory logic, despite drastic sequence divergence, in Halocynthia and Ciona.
Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans
Two related transcription factors, Zic1 and Zic2, are essential to control the balance between two defined neuron types in the postnatal brain and it is shown that this mechanism is conserved in evolutionary very distant species.
Lineage programming: navigating through transient regulatory states via binary decisions.
How targets select activation or repression in response to Wnt
How the key transcriptional mediator of the Wnt pathway, the TCF family member POP-1, regulates opposite target genes during C. elegans development is discussed and findings suggesting that the direction of the transcriptional output can be determined by the way TCF is recruited and physically interacts with its target gene are examined.