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Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP.
Neural Cell Adhesion Molecule-Stimulated Neurite Outgrowth Depends on Activation of Protein Kinase C and the Ras–Mitogen-Activated Protein Kinase Pathway
- K. Kolkova, V. Novitskaya, N. Pedersen, V. Berezin, E. Bock
- Biology, ChemistryJournal of Neuroscience
- 15 March 2000
It is proposed that PKC serves as the link between the two pathways activating Raf and thereby creating the sustained activity of the MAP kinases necessary for neuronal differentiation, and this model of NCAM signaling involving two pathways is proposed.
Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion.
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking
Although FGF-2 causes the FGFR to be internalized and degraded, NCAM gets cells moving by stabilizing the receptor, promoting receptor recycling, and initiating a promigratory signaling cascade.
Structural biology of NCAM homophilic binding and activation of FGFR
- V. Kiselyov, V. Soroka, V. Berezin, E. Bock
- Biology, ChemistryJournal of Neurochemistry
- 1 September 2005
Evidence is provided that FGFR is probably activated by NCAM very differently from the way by which it is activated by FGFs, reflecting the different conditions for NCAM-FGFR and FGF–FGFR interactions.
Regulators of Neurite Outgrowth: Role of Cell Adhesion Molecules
The structure, function, and signaling of three key CAMs found in the nervous system are described: N‐cadherin and two Ig‐CAMs, L1 and the neural cell adhesion molecule NCAM.
Zippers Make Signals: NCAM-mediated Molecular Interactions and Signal Transduction
- P. S. Walmod, K. Kolkova, V. Berezin, E. Bock
- Biology, ChemistryNeurochemical Research
- 1 November 2004
The neural cell adhesion molecule, NCAM, is involved in multiple cis- and trans-homophilic interactions (NCAM binding to NCAM) thereby facilitating cell–cell adhesion through the formation of…
The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor
It is shown that an oligomeric, but not a dimeric form of the Mts1(S100A4) protein was capable of enhancing the endothelial cell motility in vitro and stimulate the corneal neovascularization in vivo and might induce tumor progression via stimulation of angiogenesis.
Fra-1 Induces Morphological Transformation and Increases In Vitro Invasiveness and Motility of Epithelioid Adenocarcinoma Cells
It is shown here for the first time that the expression of exogenous Fra-1 in epithelioid cells results in morphological changes that resemble fibroblastoid conversion, which suggest a critical role of theFra-1 protein in the development of epithelial tumors.
NCAM‐induced intracellular signaling revisited
This review presents and discusses the current knowledge in the area of NCAM signaling with a focus on the events involved in NCAM‐mediated neurite outgrowth.