• Publications
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Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
TLDR
This review deals with the molecular physiology of spectrin, ankyrin, which links spectrin to the anion exchanger, and two spectrin-associated proteins that promote spectrin interactions with actin: adducin and protein 4.1.
A Common Ankyrin-G-Based Mechanism Retains KCNQ and NaV Channels at Electrically Active Domains of the Axon
TLDR
Con concerted ankyrin-G interaction with KCNQ and NaV channels appears to have arisen through convergent molecular evolution, after the division between invertebrate and vertebrate lineages, but before the appearance of the last common jawed vertebrate ancestor.
AnkyrinG Is Required for Clustering of Voltage-gated Na Channels at Axon Initial Segments and for Normal Action Potential Firing
TLDR
It is demonstrated that ankyrinG is essential for clustering NaCh and neurofascin at axon initial segments and is required for physiological levels of sodium channel activity.
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
TLDR
It is reported that a loss-of-function (E1425G) mutation in ankyrin-B, a member of a family of versatile membrane adapters, causes dominantly inherited type 4 long-QT cardiac arrhythmia in humans.
AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier.
TLDR
A new ankyrin gene is characterized, expressed in brain and other tissues, that is subject to extensive tissue-specific alternative mRNA processing and has a predicted globular head domain, with membrane- and spectrin-binding activities, as well as an extended "tail" domain.
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
TLDR
Results support the conclusion that ankyrin-G coordinates the physiological assembly of a protein complex containing transmembrane adhesion molecules, voltage-gated sodium channels, and the spectrin membrane skeleton at axon initial segments.
Developmental mechanism of the periodic membrane skeleton in axons
TLDR
It is found that this structure emerged early during axon development and propagated from proximal regions to distal ends of axons and that ankyrin B is critical for the polarized distribution of βII spectrin in neurites.
Molecular composition of the node of Ranvier: identification of ankyrin- binding cell adhesion molecules neurofascin (mucin+/third FNIII domain- ) and NrCAM at nodal axon segments
TLDR
This is the first characterization of defined neuronal cell adhesion molecules localized to axonal membranes at the node of Ranvier of myelinated axons.
Spectrin-based membrane skeleton: a multipotential adaptor between plasma membrane and cytoplasm.
  • V. Bennett
  • Chemistry
    Physiological reviews
  • 1 October 1990
TLDR
Spectrin-Based Membrane Skeleton: A Multipotential Adaptor Between Plasma Membranes and Cytoplasm should read BenNETT, H., and J. CONDEELIS, J.
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