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Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.
- C. S. Raymond, J. R. Kettlewell, B. Hirsch, V. Bardwell, D. Zarkower
- BiologyDevelopmental biology
- 15 November 1999
Based on sequence, map position, and expression patterns, it is suggested that Dmrt1 is likely to play a role in vertebrate sexual development and therefore that DM domain genes may play a roles in sexual development in a wide range of phyla.
The POZ domain: a conserved protein-protein interaction motif.
A novel zinc finger protein, ZID, which contains a 120-amino-acid conserved motif present in a large family of proteins that includes both the otherwise unrelated zinc finger proteins and a group of poxvirus proteins, is described.
Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.
- C. S. Raymond, M. Murphy, M. G. O’Sullivan, V. Bardwell, D. Zarkower
- BiologyGenes & development
- 15 October 2000
It is shown that murine Dmrt1 is essential for postnatal testis differentiation, with mutant phenotypes similar to those caused by human chromosome 9p deletions that remove the gene.
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors
It is demonstrated that ETO interacts with the nuclear receptor corepressor N-CoR, the mSin3 corepressors, and histone deacetylases, suggesting that it is a component of one or more core pressor complexes.
A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.
It is shown by fluorescence in situ hybridization analysis that both genes are deleted in the smallest reported sex-reversing 9p deletion, suggesting that gonadal dysgenesis in 9p-deleted individuals might be due to combined hemizygosity of D MRT1 and DMRT2.
BCoR, a novel corepressor involved in BCL-6 repression.
The specificity of the B CL-6/BCoR interaction suggests that BCoR may have a role in BCL-6-associated lymphomas and specific class I and II histone deacetylases (HDACs) interact in vivo with B coR, suggesting that B CoR may functionally link these two classes of HDACs.
Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR
The zebrafish ortholog of BCOR was cloned and found that knock-down of this ortholog caused developmental perturbations of the eye, skeleton and central nervous system consistent with the human syndromes, confirming that BCOR is a key transcriptional regulator during early embryogenesis.
Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets
- M. Gearhart, C. Corcoran, J. A. Wamstad, V. Bardwell
- BiologyMolecular and Cellular Biology
- 15 September 2006
The recruitment of two distinct classes of E3 ubiquitin ligases and a histone demethylase by BCOR suggests that BCOR uses a unique combination of epigenetic modifications to direct gene silencing.
The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.
The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT
The demonstration that N-CoR and SMRT interact with the POZ domain containing proteins indicates that these co-repressors are likely involved in the mediation of repression by multiple classes of repressors and may explain, in part, how POz domain containing repressor mediate transcriptional repression.