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The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review.
TLDR
The ongoing situation of human malaria in the Brazilian Amazon, where it is endemic causing over 610,000 new acute cases yearly, is discussed, a number which is on the increase and new antimalarial drugs are urgently needed. Expand
New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids.
TLDR
It was demonstrated that crude extracts from roots prepared with 80% ethanol by percolation are active in vitro against Plasmodium falciparum and the activity is correlated with the presence of polyacetylene and flavonoids. Expand
Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil.
TLDR
Only Remijia ferruginea showed antimalarial activity, reducing parasitaemia and mortality at the highest dose tested, and its phytochemical analysis showed the presence of alkaloids but not quinine. Expand
Ampelozyziphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites.
TLDR
Strong evidence is presented that the ethanolic extract of "Indian beer" roots hampers in vitro and in vivo development of Plasmodium berghei sporozoites, a rodent malaria parasite, which validates the use of " Indian beer" as a remedy for malaria prophylaxis in the Amazon. Expand
Antimalarial activity of Bidens pilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities or plants cultivated in humus soil
TLDR
Ethanol extracts from wild plants collected in three different regions of Brazil and from plants cultivated in various soil conditions were tested, and the wild plants were the most active, indicating a good candidate for pre‐clinical tests as a phytotherapeutic agent or for chemical isolation of the active compounds. Expand
Occurrence of anti-Toxoplasma gondii antibodies in meat and dairy goat herds in Rio Grande do Norte, Brazil.
TLDR
Most of the animals presented chronic infection among goats in Sertão do Cabugi, with a consequent great impact on the development of the goat production system and a risk to human health. Expand
Pathogenicity and phenotypic sulfadiazine resistance ofToxoplasma gondii isolates obtained from livestock in northeastern Brazil
TLDR
Atypical pathogenicity and sulfadiazine resistance profiles of T. gondii obtained from livestock intended for human consumption were reported and served as a warning to local health authorities. Expand
Anti-Toxoplasma Activity of Estragole and Thymol in Murine Models of Congenital and Noncongenital Toxoplasmosis
TLDR
Estragole and thymol display important anti-Toxoplasma activity and are effective against T. gondii ME49 strain, and orally administered estragole in infected pregnant mice improved the weight of offspring compared with untreated controls. Expand
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