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Cholinomimetic and calcium channel blocking activities of Carthamus oxycantha
The results indicate that Carthamus oxycantha contains a combination of spasmogenic (cholinergic) and spasmolytic (calcium antagonist) constituents. Expand
Lapachol: An overview
Lapachol is a naphthoquinone that was first isolated by E. Paterno from Tabebuia avellanedae (Bignoniaceae) in 1882. A wide spectrum of therapeutic activities have been attributed to lapachol or itsExpand
Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L.
Data indicate that Nepeta cataria possesses spasmolytic and myorelaxant activities mediated possibly through dual inhibition of calcium channels and PDE, which may explain its traditional use in colic, diarrhea, cough and asthma. Expand
Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy.
The cholinesterase inhibitory potential along with calcium-channel blocking activity of compound 1 and safe profile in human neutrophils viable assay could make it a possible drug candidate for Alzheimer's disease. Expand
Epimers from the leaves of Calophyllum inophyllum
The ethanolic extract of the fresh leaves of Calophyllum inophyllum afforded a pair of new epimers named as inophynone and isoinophynone. Their structures were elucidated with the aid ofExpand
Antimicrobial screening of some Caesalpiniaceae
The hexane and methanol extracts of sixteen plants of the family Caesalpiniaceae, collected around Karachi, Pakistan, were phytochemically screened and tested for their antibacterial andExpand
Cytotoxic activity of marine macro‐algae on Artemia salina (Brine shrimp)
A total of 22 ethanol extracts of seaweed species collected from the Karachi coast were investigated for brine shrimp cytotoxicity and only six namely Stoechospermum marginatum, Sargassum swartzii, S. binderi, Spatoglossum asperum, Stokeyia indica and Caulerpa racemosa showed significant activity. Expand