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Protein kinase A regulates calcium permeability of NMDA receptors
Calcium (Ca2+) influx through NMDA receptors (NMDARs) is essential for synaptogenesis, experience-dependent synaptic remodeling and plasticity. The NMDAR-mediated rise in postsynaptic Ca2+ activatesExpand
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Protein kinase C modulates NMDA receptor trafficking and gating
Regulation of neuronal N-methyl-d-aspartate receptors (NMDARs) by protein kinases is critical in synaptic transmission. However, the molecular mechanisms underlying protein kinase C (PKC)Expand
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Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression
NMDA receptors (NMDARs) colocalize with postsynaptic density protein-95 (PSD-95), a multivalent synaptic scaffolding protein and core component of the postsynaptic density, at excitatory synapses.Expand
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mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C
Potentiation of ionotropic glutamate receptor activity by metabotropic glutamate receptors (mGluRs) is thought to modulate activity at glutamatergic synapses in the hippocampus. However, the preciseExpand
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Insulin promotes rapid delivery of N-methyl-d- aspartate receptors to the cell surface by exocytosis
Insulin potentiates N-methyl-d-aspartate receptors (NMDARs) in neurons and Xenopus oocytes expressing recombinant NMDARs. The present study shows that insulin induced (i) an increase in channelExpand
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Diversity and properties of connexin gap junction channels.
Gap junction channels are composed of two apposing hemichannels (connexons) in the contiguous cells and provide a direct pathway for electrical and metabolic signaling between adjacent cells. TheExpand
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Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking
Regulation of neuronal NMDA receptors (NMDARs) by group I metabotropic glutamate receptors (mGluRs) is known to play a critical role in synaptic transmission. The molecular mechanisms underlyingExpand
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beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current.
beta3-adrenergic receptor (beta3-AR) activation produces a negative inotropic effect in human ventricles. Here we explored the role of beta3-AR in the human atrium. Unexpectedly, beta3-AR activationExpand
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Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factorsExpand
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Beta-2 adrenergic activation of L-type Ca++ current in cardiac myocytes.
The whole-cell patch-clamp and intracellular perfusion techniques were used for studying the effects of a beta-2 adrenergic receptor activation on the L-type Ca current (ICa) in frog ventricularExpand
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