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Electroporation-Induced Electrosensitization
TLDR
For varied experimental conditions, EPs triggered a delayed and gradual sensitization to EPs, and the lethality in EP-treated cells could be increased from 0 to 90% simply by increasing the exposure duration, or the exposure dose could be reduced twofold without reducing the effect. Expand
Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media.
TLDR
It is concluded that nsPEF can generate both extracellular (electrochemical) and intracellular ROS, including H(2)O(2), and possibly other species, which may lead to cell stimulation and/or oxidative cell damage. Expand
Selective cytotoxicity of intense nanosecond-duration electric pulses in mammalian cells.
TLDR
The cytotoxic effect of 10-ns EP (quantitation, mechanisms, efficiency, and specificity) in comparison with 300-ns, 1.8- and 9-μs EP was explored, which can selectively target certain cells in medical applications like tumor ablation. Expand
Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma
TLDR
The results of the study indicate that E 2 allele might be associated with concurrent occurrence of EH and ECa and HFE minor allele G (63Asp) had a protective effect in the ECa group, though these results appeared to be nonsignificant after correction for multiple comparisons. Expand
Delayed hypersensitivity to nanosecond pulsed electric field in electroporated cells
TLDR
It is demonstrated that conditioning of mammalian cells by electroporation with nanosecond pulsed electric field (nsPEF) facilitates their response to the next nsPEF treatment, and the delayed hypersensitivity was not mediated by either cell swelling or oxidative effect of the conditioning treatment. Expand
[The polymorphism of catechol-O-methyltransferase (COMT) and hemochromatosis (HFE) genes in the radiocontaminated regions residents with different chromosome aberration frequency].
TLDR
Heterozygotes for G1947A COMT and C187G HFE reveal negative association with the high frequency of chromosome aberrations and correspond to "resistance factors". Expand
Polymorphism of genes for catechol-O-methyltransferase (COMT) and hemochromatosis (HFE) in residents of radiocontaminated regions varying in chromosome aberration frequency
TLDR
The association between polymorphisms in the COMT and HFE genes, involved in oxidative stress control, and chromosome aberration frequency in lymphocytes, is analyzed in 278 women residents of radiocontaminated sites in Central Russia. Expand
[The molecular, cellular and systemic mechanisms of the radioprotective action of multivitamin antioxidant complexes].
TLDR
Use of water-dispersed forms of beta-carotene with addition of vitamins E and C protected thymus against cellular devastation induced by irradiation and stress, and increased the efficiency of DNA repair in spleen of irradiated mice. Expand
COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study)
Цель: оценка влияния SNP val158met гена COMT на эффективность спинальной аналгезии в 1 сутки после лапароскопических операций по поводу колоректального рака. Материал и методы. В пилотномExpand
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