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Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata
TLDR
It is believed that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions believed to be effective against pathogenic elements of the wound microbial flora. Expand
Serine/threonine protein phosphatases in the control of cell function.
Reversible protein phosphorylation is a fundamental mechanism by which many biological functions are regulated. Achievement of such control requires the coordinated action of the interconvertingExpand
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Recently, we have isolated and characterized remarkable antimicrobial peptides (AMPs) from the venom reservoirs of wild bees. These peptides (melectin, lasioglossins, halictines and macropin) andExpand
Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae)
TLDR
Three novel structurally related pentadecapeptides, named lasioglossins, were isolated from the venom of the eusocial bee Lasioglossum laticeps and exhibited potent antimicrobial activity against both Gram‐positive and Gram‐negative bacteria, low haemolytic and mast cell degranulation activity, and a potency to kill various cancer cells in vitro. Expand
Melectin: A Novel Antimicrobial Peptide from the Venom of the Cleptoparasitic Bee Melecta albifrons
TLDR
The results of biological testing suggest that a Pro kink in the α‐helical structure of melectin plays an important role in selectivity for bacterial cells. Expand
Antimicrobial Peptides for Topical Treatment of Osteomyelitis and Implant-Related Infections: Study in the Spongy Bone
TLDR
The results of the experiments performed in human bone tissue highlight the clinical potential of antimicrobial peptides for use in treating and preventing osteomyelitis caused by resistant pathogens. Expand
The applicability of subtilisin carlsberg in peptide synthesis
TLDR
Contrary to the published data, it is proved that proline derivatives were not acylated in any media with the help of subtilisin Carlsberg, and it is demonstrated that the yields of peptide products were higher in most cases when acetonitrile with low H2O concentration was used. Expand
New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs
TLDR
Four new peptides of the mastoparan family synthesized and tested for antimicrobial potency against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa showed that the peptides might adopt alpha-helical conformation in such anisotropic environments. Expand
Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy
TLDR
The decades-long story of the effort to isolate and characterise lucifensins from the bodies of medicinal larvae or from their secretions/excretions is discussed and its ability to enhance host immunity by functioning as immunomodulator is discussed. Expand
Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
TLDR
The total chemical synthesis of this peptide of 40 amino acid residues and three intramolecular disulfide bridges by using three different protocols yielded a peptide with a pattern of disulfides bridges identical to that of native lucifensin. Expand
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