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Tumor antigens (CEA and AFP) were studied by radioimmunoassay and immunoglobulins A, M and G--after Mancini in blood plasma from 144 cases of colorectal cancer. In most patients, raised levels of CEA, AFP, IgA and IgG were identified. A 5-10-fold increase in CEA and AFP levels matched by a pronounced dysimmunoglobulinemia or IgG deficit (under 10 mg/ml)… (More)