V. Yu. Gorbatov

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Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ25-35 in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage restores learning capacity of(More)
Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of(More)
Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment Aβ25-35 into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h(More)
Increased production of autoantibodies to glutamate was found in blood plasma from patients with Alzheimer’s dementia. The content of autoantibodies to glutamate in patients with early-onset Alzheimer’s disease was much lower than in those with lateonset Alzheimer’s disease (1.40±0.07 and 1.80±0.07 arb. units, p<0.001). The level of autoantibodies to(More)
The rat model of Alzheimer’s disease including injection of neurotoxic fragment of β-amyloid protein Aβ25–35 into giant-cell nuclei basalis of Meynert was used for experiments. We have investigated the influence of glutamate antibodies administered intranasally in a dose of 300 μg/kg after 1 h of the mentioned alteration on the level of expression of Dffb(More)
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