V. Ya. Shevlyagin

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The ability of different recombinant vaccinia viruses (RVV) expressing hepatitis B virus surface antigen (HBsAg) to induce anti-HBs and anti-vaccinia virus responses has been analyzed in mice. The RVVs tested differed with regard to the original vaccinia virus strain used as vector and the site of insertion of a foreign gene. It was found that the(More)
Experiments were staged for the evolvement of immunogical tolerance in adult rabbits with the aid of 6-mercaptopurine. After the administration of human serum albumin together with antimetabolite to rabbits, the animals formed no antibodies in response to subsequent albumin injection. This stage of tolerance continued for a period of not more than 4 months.(More)
PPLO were isolated from the transplantable cellular strains HeLa, CaVe, Cois, Hep-2 and human amnion, as well as from the primary tissue of mouse embryo. Microorganisms isolated from HeLa and CaVe were highly resistant to penicillin and streptomycin. Not in a single case was it possible to isolate PPLO from the 10 cultures of chick embryos. One of the(More)
A line of human embryonic fibroblasts, transformed by Rous sarcoma virus (Schmidt-Ruppin strain) contained and produced Rous virus, as was shown by the complement fixation and immunofluorescent tests, by electron-microscopic investigation, and by the presence of an isotope peak in a sucrose gradient. By its biological properties the synthesized virus(More)
Mouse antiserum against isologous heat-aggregated immunoglobulins (MAAS), on repeated injection into animals, prolonged the survival of skin allografts, facilitated the development of Moloney sarcoma, reduced the latent period of appearance of tumors, sharply increased the yield of tumors which in most cases led to death of the mice, disturbed the normal(More)
Af te r the d i s c o v e r y of the pa thogenic i ty and oneogenic i ty of Rous v i rus for r a t s and rabb i t s [1,3] the r e l a t ionsh ip between this v i rus and the t i s sues of va r ious m a m m a l s was s tudied by many inves t i ga to r s [58]. However , e v e n now the p o s s i b i l i t i e s and e s s e n t i a l condit ions for syn thes i(More)
A prev ious inves t iga t ion [4] showed that t umors induced in adult outbred W i s t a r r a t s by Rous v i rus of the Schmidt-Ruppin s t r a in can be v i rogen ic , " v i r u s f r e e , " and in ve ry r a r e ca ses they may contain v i rus in the mature fo rm. P a r t i c u l a r i n t e r e s t is a t tached to the " v i r u s f r e e " t umors in(More)
Transformed cells secrete substances which can induce proliferation of the same or other cells in semisolid agar [4]. These substances are known as tumor growth factors (GF) [2]. Various techniques can be used to detect GF, among which the most important is the study of conditioned culture fluid (CCF) [2, 7-9] or of acid-ethanol cell extracts [i0] for the(More)
In the human fibroblasts culture, transformed by the material from malignant paraganglioma culture, there was found the RNA- and DNA containing virus synthesis. The RNA-containing virus with a buoyant density of 1.16--1.18 g/ml shows no hemagglutinating activity, it fails to infect newborn Syrian hamsters, and produces no transformation-destruction changes(More)