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Poly(C)-avid ribonucleases of molecular weight 33 000 are present in the serum, cerebrospinal fluid and urine of humans. Purified human urinary ribonuclease was used to produce a monospecific antibody in rabbits. The antibody was capable of: (i) inhibiting the enzyme activities in the serum, CSF, and urine; (ii) reacting with antigens in the serum and CSF.(More)
The ribonuclease activity of cerebrospinal fluid of 219 patients was studied. The normal level was 269 +/- 95 units/ml. Consistent elevations above 550 units/ml were found in: 1. Chronic cerebrovascular disease; 2. Spinal cord compression; 3. Tumors. The molecular weights of the ribonucleases in the cerebrospinal fluid are approximately 33,000; 21,000 and(More)
ROS are implicated in bone diseases. NADPH oxidase 4 (NOX4), a constitutively active enzymatic source of ROS, may contribute to the development of such disorders. Therefore, we studied the role of NOX4 in bone homeostasis. Nox4(-/-) mice displayed higher bone density and reduced numbers and markers of osteoclasts. Ex vivo, differentiation of monocytes into(More)
OBJECTIVE Analysis of lymphocele´s incidence and therapy among the patients, who underwent systematic pelvic and paraaortic lymphadenectomy during the years 2010-2012 in Oncogynecological centre of Department of Gynecology and Obstetrics in Brno. DESIGN Retrospective study. SETTING Department of Gynecology and Obstetrics, Masaryk University Hospital(More)
INTRODUCTION Octreotide is a synthetic analogue of natural somatostatin. Octreotide effect on lymphorrhea reduction in gynecological malignancies has only been assessed in case studies. DESIGN Original work. SETTING Gynecologic Oncology Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno.(More)
OBJECTIVE Analysis of two cases of incarcerated uterus during pregnancy. DESIGN Two case reports. SETTING Department of Gynecology and Obstetrics, Masaryk University, University Hospital Brno. METHODS AND RESULTS In two cases of incarcerated uterus, which were resolved on Department of Gynaecology and Obstetrics, University Hospital Brno is shown a(More)
OBJECTIVE The overview of vascular anatomy and abnormalities of retroperitoneal pelvic and paraaortic area in relation to the radical oncogynecological surgery. DESIGN Retrospective study. SETTING Gynecologic Oncology Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno. MATERIAL AND(More)
OBJECTIVE Analysis of radical fertility preserving surgery, oncogynaecological treatment including their pregnancy effort. DESIGN Prospective study. SETTING Department of Obstetrics and Gynaecology, Masaryk University and Faculty Hospital Brno. METHODS The group of 13 patients in age fifteen to thirty-six, who underwent radical fertility preserving(More)
In the last decade we have witnessed a stormy development in the field of molecular biology, immunology and genetics. Dramatic advances in laboratory and clinical procedures in cellular immunotherapy, along with the development of powerful immunomodulatory agents, created new conditions and opportunities in the treatment of ovarian cancer. The review(More)