V. V. Yaglov

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The mechanism of disruptive action of dichlorodiphenyltrichloroethane (DDT) on the function of thyroid follicular epitheliocytes was examined in mature male Wistar rats administered with a daily dose of DDT (2 μg/kg) for 6 or 10 weeks. In 6 weeks, the serum level of Na+/I – symporter responsible for the transport of iodides into follicular thyrocytes(More)
The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased concentrations of thyroid hormones,(More)
BACKGROUND The combined oral contraceptive containing ethinylestradiol and the selective progestogen, desogestrel, in a phasic regimen (DSG-OC, Tri-merci) has been shown to reduce facial oiliness. OBJECTIVE This study was designed to evaluate further the effects of this OC on the skin of women with facial seborrhea and mild or moderate acne. DESIGN AND(More)
The search for therapeutic preparations with effective antisilicotic properties is an urgent task in biology and medicine. Piracetam (2-pyridylethylmethacrylate-phosphate) under experimental conditions is known to possess such an action [1]. However, its clinical use for the treatment of silicosis and other types of pneumoconiosis, accompanied by the(More)
Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron microscopy of thyroid gland samples revealed(More)
Changes in secretion of thyroid autoantigenes and production of antithyroid autoantibodies after long-term exposure to low doses of DDT were studied. Changes in serum levels of antithyroid peroxidase antibodies and thyroid peroxidase, attributed to disruption of thyroxine production by DDT were found. Long-term exposure of rats to low doses of DDT revealed(More)
We studied the effects of prenatal and postnatal exposure to low doses of DDT on secretion of basic catecholamines epinephrine and norepinephrine in pubertal and adult rats. It was found that the endocrine-disrupting chemical under study led to a progressive decrease in the content of epinephrine and especially norepinephrine in systemic circulation, which(More)
Anurgent problem in contemporary morphology is the study of the structural organization and function of the regulatory and integrative systems of the body. The study of the diffuse endocrine system (DES), formed by a combination of hormone-producing cells, most of which are located in epithelial tissues which occupy a boundary position between the external(More)
  • V. V. Yaglov
  • Bulletin of Experimental Biology and Medicine
  • 2004
Intraperitoneal injection of alloxan into terrapinsTestudo horsfieldi andClemmys caspica in a dose of 300 mg/kg caused destructive and metabolic changes in cells of both the endocrine and exocrine parts of the pancreas. The granular cytoplasmic reticulum in the acinar cells and the mitochondria in the centroacinar cells underwent focal destruction. Hydropic(More)