V V Tugarinov

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BACKGROUND The protein 0.5beta is a potent strain-specific human immunodeficiency virus type 1 (HIV-1) neutralizing antibody raised against the entire envelope glycoprotein (gp120) of the HIV-1(IIIB) strain. The epitope recognized by 0.5beta is located within the third hypervariable region (V3) of gp120. Recently, several HIV-1 V3 residues involved in(More)
The solution structure of a recombinant active alpha-neurotoxin from Leiurus quinquestriatus hebraeus, Lqh(alpha)IT, was determined by proton two-dimensional nuclear magnetic resonance spectroscopy (2D NMR). This toxin is the most insecticidal among scorpion alpha-neurotoxins and, therefore, serves as a model for clarifying the structural basis for their(More)
The effect of "hole burning" in absorption spectrum upon monochromatic illumination at 4.2 degrees K has been investigated on the Chlamydomonas reinhardii mutant strain 516-3a which possesses the chlorophyll a/P700 ratio of about 25. This effect has been earlier discovered for the wild type strain of Chlorella. In the strain 516-3a two types of holes(More)
Spectral and photochemical parameters were described of the mutant strain of Chlamydomonas reinhardii 516--3a, in which the ratio chlorophyll a/P700 is about 20. Experiments were carried out with this strain for investigating earlier observed for Chlorella effect of burning out of deeps in absorption spectra at 4.2K resulting from irradiation with(More)
We describe solid state NMR measurements on frozen solutions of the complex of the 24-residue HIV-1 gp120 V3 loop peptide RP135 with the Fab fragment of the anti-gp120 antibody 0.5beta, using rotational echo double resonance (REDOR). In order to probe possible hydrogen bonding between arginine side chains and glycine backbone carbonyls in the region of the(More)