V. V. Rakitskaya

Learn More
Lipid peroxidation processes were studied in the striatum during stress in conditions of prior administration of cortisol. Three doses of cortisol (25 mg/kg, daily) had no significant effect on the levels of lipid peroxidation products six days after injections ended. However, lipid peroxidation responses to stress during this period in animals given(More)
In situ hybridization was used to study the distribution of corticoliberin receptors of subtypes 1 and 2 (CL-R1 and CL-R2 respectively) in different structures of the rat brain. Levels of CL-R1 mRNA in the brain were significantly greater than levels of CL-R2 mRNA, and the most intense expression of the CL-R1 gene was seen in forebrain structures,(More)
The effects of intranasal corticoliberin on behavior in the open field test were studied in rats with active and passive behavioral strategies (lines KHA and KLA); levels of dopamine and noradrenaline and their metabolites were measured in the striatum and hypothalamus. In KLA rats, administration of the neurohormone led to increases in motor and(More)
The behavioral and neuroendocrine responses of the body to external changes are determined by genetically determined programs of individual development, and are established during pre- and post-natal ontogenesis. These responses, however, can be changed by stress or administration of corticosteroid hormones in “critical periods” of the body's development.(More)
Chronic experiments on rabbits showed that bilateral electrolytic destruction of dorsomedial and ventromedial hypothalamic nuclei lowers the basal blood corticosteroid levels. Stimulation of the dorsal tegmentum, which in intact animals causes the blood corticosteroids to rise, no longer leads to an increase in the adrenocortical hormone level after(More)
A conditioned active avoidance response was developed in rats with high (KHA) and low (KLA) rates of learning and the effects of injection of corticoliberin into the dorsal striatum on orientational-investigative and avoidance behavior were studied in normal animals and after depletion of striatal dopamine by preliminary injection of 6-hydroxydopamine.(More)
Changes in the activity of the hypothalamo-hypophyseal-adrenocortical system (HHAS) were studied in adult prenatally stressed female rats in an experimental model of post-traumatic stress disorder (PTSD) in which the animals were subjected to combined treatment consisting of restraint for 2 h, swimming for 20 min, and ether stress, with subsequent restress(More)
Studies reported here show that intrastriatal administration of corticoliberin to rats decreases the blood testosterone level. However, in conditions of chemical deficiency of dopaminergic transmission in the dorsal striatum induced by injection of 6-hydroxydopamine, the effect of this neurohormone did not appear. It is concluded that extrahypothalamic(More)
Changes in activity of the hypothalamic–pituitary–adrenal (HPA) axis were examined in adult, prenatally stressed male rats in the experimental depression model of ‘learned helplessness’. It was shown that in males descending from intact mothers a depressive-like state was accompanied by an increase in activity of the entire HPA axis. Namely, expression of(More)
Active and passive Wistar rats were subjected to single water immersions, after which they showed signs of post-stress depression. Administration on this background of the peptide CRH-R1 receptor blocker astressin prevented the development of behavioral deficit in active individuals but had no effect on the behavior of passive rats. These results lead to(More)