V. V. Pilipenko

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Although the technical and analytic complexity of whole genome sequencing is generally appreciated, best practices for data cleaning and quality control have not been defined. Family based data can be used to guide the standardization of specific quality control metrics in nonfamily based data. Given the low mutation rate, Mendelian inheritance errors are(More)
Mortality associated with acute lung injury (ALI) remains substantial, with recent estimates of 35-45% similar to those obtained decades ago. Although evidence for sex-related differences in ALI mortality remains equivocal, death rates differ markedly for age, with more than 3-fold increased mortality in older versus younger patients. Strains of mice also(More)
We compare simultaneous observations of long-period ultra-low-frequency (ULF) wave activity from a Sval-bard/IMAGE fluxgate magnetometer latitudinal profile covering the expected cusp geomagnetic latitudes. Irregular Pulsations at Cusp Latitudes (IPCL) and narrowband Pc5 waves are found to be a ubiquitous element of ULF activity in the dayside high-latitude(More)
Family based association studies are employed less often than case-control designs in the search for disease-predisposing genes. The optimal statistical genetic approach for complex pedigrees is unclear when evaluating both common and rare variants. We examined the empirical power and type I error rates of 2 common approaches, the measured genotype approach(More)
The presented results, concerning the features of the solar wind plasma structure as observed by spacecraft upstream of Earth, could be used for development of middle-term forecasts of magnetic storms. We have analyzed 1-hour data for 1995-2005 and a whole year of 1-min data during solar minimum (1995) and during solar maximum (2000) with 48 and 60 storms,(More)
Microarray testing has revolutionized clinical cytogenetics, as it provides a significantly higher resolution and greater clinical yield than karyotype analysis. This study assessed the clinical utility of single-nucleotide polymorphism microarray in patients with epilepsy. Study subjects were patients between the ages of birth to 23 years who were(More)
Population substructure is a well-known confounder in population-based case-control genetic studies, but its impact in family-based studies is unclear. We performed population substructure analysis using extended families of admixed population to evaluate power and Type I error in an association study framework. Our analysis shows that power was improved by(More)
Cotinine is a proxy for secondhand smoke (SHS) exposure. Genetic variation along nicotine and cotinine metabolic pathways may alter the internal cotinine dose, leading to misinterpretations of exposure-health outcome associations. Caucasian children with available SHS exposure and hair cotinine data were genotyped for metabolism-related genes. SHS-exposed(More)
The present study examined the association of dopamine-related genes with short- and long-term neurobehavioral recovery, as well as neurobehavioral recovery trajectories over time, in children who had sustained early childhood traumatic brain injuries (TBI) relative to children who had sustained orthopedic injuries (OI). Participants were recruited from a(More)
The onset of anomalous resistance in a layer on auroral field lines is shown to be accompanied by the excita-tion of an Alfvénic impulse (AI). The generated AI marks the transition of the global magnetosphere-ionosphere instability into an explosive phase with positive feedback. The spatial structure of this impulse both in space and on the ground has been(More)