V. V. Khorobrykh

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The indirect (through the lymphocytes) act ion of ant i lymphoeytic globulin (ALG) on the abil i ty of bone m a r r o w cel ls to fo rm hematopoie t ic colonies in lethal ly i r rad ia ted (830 rad) mice was investigated. Lymphocytes t r ea t ed in v i t ro with ALG have the i r functional s ta te modified and, if injected toge ther with intact bone m a r r(More)
The number of transient endogenous spleen colonies (TEC) formed on days 4-6 postirradiation was found to be greatly increased in mice inoculated with M. arthritidis 1 day prior to sublethal irradiation. In irradiated plethoric mice, TEC formation was reduced (about 10-fold), but preinfection with M. arthritidis reversed the effect of plethora, and TEC(More)
Mycoplasma arthritidis was shown not to affect endogenous colony formation in lethally irradiated BALB/c mice. The number of endogenous foci in mice irradiated in sublethal doses and infected withM. arthritidis was sharply increased when the mycoplasma was injected 24 h before or 4 h after irradiation. Mixed infection of (C57BL/6×A/Sn)F1 mice resistant to(More)
The treatment of tumour and lymphoid cells of mice with 3M KC1 solution having high ionic strength, nonionic detergent and by subsequent freeze-thawing resulted in obtaining serologically active H-2 antigen preparation capable of specifically blocking the cytotoxicity of H-2 antisera. The antigenic activity of the preparations thus obtained depended on the(More)
A method of obtaining antisera against isologous aggregated mouse immunoglobulins is described. This serum designated MAAS blocked in vitro the antigen-binding receptors of the immune rosette-forming cells. MAAS was injected to mice immunized with SRBC. In comparision with the immunized mice given normal isologous serum rosette-forming B-cells were absent(More)
The treatment in vitro of bone marrow cells in mice by phytohemagglutinin, concanavaline, or antilimphocytic globulin resulted in the suppression of exogenous hemopoietic colonies in the spleen of lethally irradiated (830r) syngenic recipients, whereas lipopolysaccharide, tuberculin, anti-theta serum or nati-gamma-globulin serum exerted no influence on the(More)
The mitogenic effect of corpuscular antigens with respect to the splenocytes of animals was found to depend on the strain of Staphylococcus aureus. The maximum synthesis of DNA in the cells was induced by corpuscular antigen Smith and the minimum synthesis, by Wood-46. The synthesis of DNA was activated in both B- and T-splenocytes in response to(More)
It was demonstrated in this work that rabbit antimouse serum against the aggregated immunoglobulins (RAAS) and mouse serum against the aggregated mouse immunoglobulins (MAAS) inhibited the rosette-forming B-cells (RFC) on the 5th day after the immunization of mice CBA with SRBC in a dose of 5 X 10(-8) cells in vitro in 1:20--1:80, and 1:10--1:40 dilutions(More)