V. V. Karpitskii

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CD2-associated protein (CD2AP) is an 80-kilodalton protein that is critical for stabilizing contacts between T cells and antigen-presenting cells. In CD2AP-deficient mice, immune function was compromised, but the mice died at 6 to 7 weeks of age from renal failure. In the kidney, CD2AP was expressed primarily in glomerular epithelial cells. Knockout mice(More)
The discovery of virtually all the biochemical components of the renin-angiotensin system in brain tissue was the basis for the study of the role of this system in central regulation of the hemodynamics under normal and pathological conditions. From the abundant data on the distribution of activity of angiotensin-converting enzyme (ACE), the key factor of(More)
An important function of the pulmonary microvessels is inactivation of the depressor peptide, bradykinin (Bk) and conversion of angiotensin I (ANG-I) into a powerful pressor factor, angiotensin II (ANG-II). These coupled processes are effected with the participation of an angiotensin-converting enzyme (ACE; EC, which is locaiized in the membrane(More)