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The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes. Activation of the channel allows the influx of(More)
1. Taurine is a ubiquitous, free amino acid found in mammalian systems. 2. The biological functions of taurine are unclear. 3. Various in vivo data suggest that taurine has a variety of protective functions and deficiency leads to pathological changes. 4. Depletion in rats of taurine increases susceptibility to liver damage from carbon tetrachloride. 5.(More)
Methylene dianiline (DAPM) causes hepatic damage and bile duct necrosis in rats. This has been detected histologically and biochemically. The toxicity was dose related over the range 0-100 mg/kg but the dose response relationship showed a maximum at about 75-100 mg/kg. This was true for both histopathology and biochemical parameters of liver dysfunction.(More)
Exposure of isolated rat hepatocytes to alpha-naphthylisothiocyanate (ANIT) results in time and dose-dependent decreases in glutathione (GSH), ATP and cell viability. When taurine (15 mm) was added to cells no protection was afforded and a drop in the initial levels of GSH was also found. Prior treatment of rats with beta-alanine (3% in drinking water) did(More)
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