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Since narcotic drugs profoundly depress breathing, we tested whether endogenous opioids influenced control of breathing in chronic obstructive pulmonary disease (COPD), reasoning that the stress of chronic dyspnea might cause elaboration of "endorphins." In 14 patients with COPD (but without respiratory failure) and eight normal controls, we measured(More)
Despite increasing clinical reliance on nocturnal penile tumescence (NPT) testing for the differential diagnosis of male impotence, little is known at present about the relationship between NPT and other aspects of sleep and waking psychophysiology. This study investigated patterns of NPT, sleep, and EEG hemispheric asymmetry in 20 male subjects, using(More)
This paper describes a system that was designed to evaluate ventilatory responses to hypercapnia, airway occlusion pressure (P100), as well as measuring ventilatory drive and timing. Parameters measured include minute ventilation (VE), breathing rate (f), tidal volume (VT), inspiratory time (TI), fractional inspiratory time (TI/TTot), mean inspiratory flow(More)
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