V Sabbah

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The serine protease thrombin (E.C.3.4.21.5) is well recognized for its central role in hemostasis. In addition, thrombin is unique among the enzymes participating in the clotting cascade, by virtue of its cell activation effects induced via the enzymatic pocket or via functional domains located throughout the molecule. In this review, we elaborate on(More)
Thrombin, in addition to its central role in hemostasis, possesses diverse cellular bioregulatory functions implicated in wound healing, inflammation, and atherosclerosis. In the present study we demonstrate that thrombin molecules modified either at the procoagulant or catalytic sites induce endothelial cell (EC) adhesion, spreading, and cytoskeletal(More)
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